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95 corporations have to rely on the public assistance provided by the Centre for Technological and Industrial Development CDTI ; , the Interministerial Commission on Science and Technology CICYT ; , the Programme for the Promotion of Technological Research PROFIT ; of the Ministry of Science and Technology, as well as the European Regional Development Funds FEDER ; [Pujol Gebelli, 2003]. Since its creation and up to 2004, some 300 million have been invested in PharmaMar, out of which 120 million have been allocated to research on Yondelis. During that period, four products have been tested in clinical trials and another 14 were in a preclinical stage. The 230 million collected in 2000 in the stock market have fueled the research and by the end of 2003, 130 million were left for funding it for another two years. PharmaMar's president was hoping that during this period a breakthrough would occur regarding Yondelis Pujol Gebelli, 2003 ; . Unfortunately the European Agency for the Evaluation of Medicinal Products EMEA ; has given a negative judgment in the first evaluation phase of Yondelis, despite the fact that PharmaMar presented at the EORTC congress in Amsterdam all the details concerning the anti-tumour activity of Yondelis, and after the failure of the two drugs generally used against sarcomas of soft tissues, doxorubicine and phosphamid. While over the 20-year period up to 2003, almost 50 products have been tested against this kind of sarcoma without success, Yondelis was the first compound that showed a specific activity. Soft-tissue sarcoma is a rare disease, representing only 1% of all forms of cancer, and this implies that it is not easy to find patients on whom any potential drug could be tested Pujol Gebelli, 2003 ; . At the initiation of phase-2 clinical trials, three patients died, because 50% of the product is metabolized in the liver and the rest is eliminated through the bile. The patients with obstructed bile ducts did not eliminate the product, so that the dosis was higher than the tolerable one. It is easy to know whether the patient has a nonobstructed bile duct through a test of alkaline phosphatase and bilirubine if this is not the case, instead of 1, 500 g m of Yondelis, 1, 200 g m are administered. With this change in the treatment protocol, there were no problems. In addition, there was no cumulative toxicity, and some patients have received more than 30 cycles, while with the other available drugs, one cannot go beyond six cycles Pujol Gebelli, 2003 ; . Despite the setback at the EMEA level, PharmaMar's president remains optimistic about the future of the company's star product. In addition to its activity against softtissue sarcoma, Yondelis was found to also have a specific activity against ovary cancer.
Clobbered the town of Greensburg, Kan. in May. She had a video camera, two still cameras and about 10 minutes before another storm swept into the area. "I shot 400 still frames and five minutes of video. I photographed everything in sight, " she said. "I was so focused on doing my job in a very short amount of time I really didn't have time to feel. It wasn't until the next day when I was able to look at my disks frame by frame that I was able to study the pictures and start to understand the enormity of it all.
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Northwest Alliance is a private investment firm focused on investments in seaport terminals in the Leningradskaia oblast. The Company recently won the tender to design and construct the Oil Terminal in Vistino, Kingiseppsky district of the Leningradskaia Oblast--a project intended to increase Russia's oil export capacity so as to compete more effectively with the former Soviet Baltic states in the transportation of Russian oil. The terminal, a part of the "Gorki" port district, will be built in the Luzhskaia Guba harbor, strategically located on the East coast of the Gulf of Finland. This location lends the project a key competitive advantage: built in the deeper part of the Gulf of Finland, it will not require that a special shipping channel be dug, an aspect that significantly reduces the project costs. North-West Alliance's winning design incorporated foreign and domestic experience in port construction, and featured cutting edge equipment in oil shipment and storage to ensure high production standards, safety, environmental protection, as well as various means of boosting the region's development.
More shelter for women in distress and more centres for child care for women who have had to leave home because of abusive relationships. More schemes to provide group housing for women living with HIV AIDS. Support to hospices being run by NGOs to assist women living in nuclear families without any support for care and nursing of the sick. Support to programs that ensure that women remain visible as workers in the labour market. The work participation rate of women will need to be increased through the provision of resources and skills to enable her to bear the economic shock of the situation.
V. SEC, 450 U.S. 91, 102 1981 SEC v. C.M. Joiner Leasing Corp., 320 U.S. 344, 355 1943 ; . Defendants contend that the Commission must prove that the statements at issue were false by "clear and convincing evidence" because "liability is sought on pure speech activity on a matter of public concern." Md. 1992 ; . See Batson v. Shiflett, 602 A.2d 1191, 1210.
With both nosocomial and community-acquired infections; nevertheless, it has remained susceptible to most antimicrobial agents. Not surprisingly, the MIC90s of the isolates tested herein were susceptible to ten antimicrobial agents with activity against staphylococci Table 2 ; . However, despite the apparent in vitro susceptibility of planktonic bacteria to most antimicrobial agents, surgery or removal of infected medical devices is often needed for treatment of deepseated S. lugdunensis infections 1, 13 ; . Two of the few known virulence factors characterized to date in S. lugdunensis are fibrinogen-binding and von Willebrand factor-binding proteins 31, 35, 36 ; . The functions of these proteins suggest that a mechanism for primary attachment to host tissues exists in S. lugdunensis, thus enabling in vivo biofilm formation. In vitro S. lugdunensis biofilms were not susceptible to drug concentrations more than ten times greater than the planktonic susceptibility breakpoints for 80% of the antimicrobial agents we evaluated for and emend.
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12. The promotion of associated industries and technologies within the broader life sciences sector should be intensified by the relevant agencies. Medical Diagnostics, for example, is an important application area for biotechnology. Enabling or supportive technologies such as Bio-informatics are also worthy of consideration, in view of Ireland's established strengths in computing, mathematics and physics at third level. The third-level institutions should support this initiative by promoting the appropriate skills in their curricula. Responsibility: Governing Authorities, Academic Councils, HEA, IBEC, IDA Ireland, Enterprise Ireland, SFI.
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Table of content 7.2 Oxygen isotope thermometry 7.3 Hydrogen isotope analyses of hydroxyl-bearing mineral separates from eclogite and gneiss from the SDT Chapter 8. METAMORPHIC EVOLUTION AND P-T CONDITIONS 8.1 The Bixiling eclogite 8.2 The Shima eclogite 8.3 The Shuanghe jadeite quartzite 8.4 The Lidu eclogite 8.5 The Raobazhai eclogite 8.6 The Yanzihe granulite 8.7 Summary of P-T conditions Chapter 9. DISCUSSION 9.1 Contrasting P-T paths between the metamorphic rocks from the SDT and NDC and emtricitabine!
The developed inhibitors which when incorporated in tap water inhibit the corrosion of cast iron, mild steel, copper, brass, aluminum, and solder, representing materials of constructions of engine cylinder head, block, radiator tube and water pump and also prevents scale formation in the circulatory system. The corrosion inhibitors are supplied in different packages e.g. larger packages for the preparations of initial coolant solution and smaller packages for the inhibition of water used for topping up. In case of loss of water in the radiator, the vehicle should be visually checked for any leakage. If there is no leakage, the radiator water is topped up with the plain water. In case of leakage, measured quantity of water is used for topping up and for each liter of water, contents of one top-up capsule is emptied in the radiator. The process involves mixing of various ingredients in a suitable proportion followed by heating.
Given the age-specific pharmacokinetic properties of CsA del Mar Fernndez de Gatta et al. 2002; Dunn 2003 ; . Thus, the present study was conducted 1 ; to reconfirm the and emtriva.
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The podiatrist's care of his her patients. The pharmacist must become knowledgeable of the primary foot disorders and their treatments. Patient education and followup monitoring are central features and tenets of pharmaceutical care that are intended to maximize patient adherence with the therapeutic plan. PharOnychogryphosis syn. Ram's horn ; , macists can advise demonstrating the distorted clubpatients and their shaped laterally deviated thickened, caregivers ; on the opaque, yellow nails. This deformity was due to onychomycosis and a proper use of prescribed medications, failure to trim the toenails. nonpharmacologic measures to alleviate symptoms and enhance therapy, and avoidance of factors that contribute to the development of certain conditions. It is extremely important that the patient has an adequate amount of medication and understands the frequency of its application, the method of application, and the amount to be applied. Further, the patient should be encouraged to adhere to the prescribed medication s ; and know what the treatment endpoint will be. Adverse effects that might occur with therapy should also be shared with the patient. Coupled with all of this should be the appropriate timing of return visits to ensure successful therapy. The pharmacist should monitor the patient's use of medications to Figure 11 ensure that the patient is realizing the maximum benefit. Further, the pharmacist should listen carefully to the patient caregiver comments during follow-up visits to the pharmacy and decide if a referral to a physician or podiatrist is advisable. Patient misconceptions about therapy, its intent, and other Plantar keratoderma features can be clari54 and enbrel.
Functions. Please see Your plan documents for a full description of the uses and disclosures the plan sponsor may make of Your medical information in such circumstances. UNDERWRITING: Your medical information may be received for underwriting, premium rating or other activities relating to the creation, renewal or replacement of a health insurance or benefits contract. If the Plan does not issue that contract, Your medical information will not be used or further disclosed for any other purpose, except as required by law. MARKETING: Your medical information may be used to provide information about healthrelated benefits, services or treatment alternatives that may be of interest to You. Your medical information may be disclosed to a business associate assisting us in providing that information to You. You may opt-out of receiving further information see the instructions for opting out at the end of this notice ; , unless the information is provided to You in a newsletter or in person or concerns products or services of nominal value. RESEARCH: The Plan's legal obligations permit Your medical information to be used or disclosed for research purposes. If You die, Your medical information may be disclosed to a coroner, medical examiner, funeral director or organ procurement organization. AS REQUIRED BY LAW: Your medical information may be used or disclosed as required by state or federal laws. COURT OR ADMINISTRATIVE ORDER: Medical information may be disclosed in response to a court or administrative order, subpoena, discovery request, or other lawful process, under certain circumstances. VICTIM OF ABUSE: If You are reasonably believed to be a victim of abuse, neglect, domestic violence or other crimes, medical information may be released to the extent necessary to avert a serious threat to Your health or safety or to the health or safety of others. Medical information may be disclosed, when necessary, to assist law enforcement officials to capture an individual who has admitted to participation in a crime or has escaped from lawful custody. MILITARY AUTHORITIES: Medical information of Armed Forces personnel may be disclosed to Military authorities under certain circumstances. Medical information may be disclosed to authorized federal officials as required for lawful intelligence, counterintelligence, and other national security activities. C. INDIVIDUAL RIGHTS You have the right to look at or get copies of Your medical information, with limited exceptions. You must make a written request, using a form available from the Privacy Office, to obtain access to Your medical information. If You request copies of Your medical information, we will charge $.25 per page, per hour for staff time required to copy that information, and postage if You want the copies mailed to You. If You request an alternative format, the charge will be based upon the Plan's cost of providing Your medical information in that format. If You prefer, the Plan will prepare a summary or explanation of Your medical information for a fee. For a more detailed explanation of the fee structure, please contact the Privacy Office. The Plan will require advance payment before copying Your medical information. You have the right to receive an accounting of any disclosures of Your medical information made by the Plan or a business associate for any reason, other than treatment, payment, health care operations purposes after April 14, 2003. This accounting will include the date the disclosure was made, the name of the person or entity the disclosure was made to, a description of the medical information disclosed, the reason for the disclosure, and certain other information. If You request an accounting more than once in a 12-month period, there may be a reasonable costbased charge for responding to those additional requests. Please contact the Privacy Office for a more detailed explanation of the fees charged for such accountings.
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The documentation required in an NDA is supposed to tell the drug's whole stor y, including what happened during the clinical tests; how the drug is constituted--its components and composition; results of the animal studies; how the drug behaves in the body; and how it is manufactured, processed and packaged. CDER requires samples of the drug and its labels. Full reports of a drug's studies must be submitted so that CDER and enfuvirtide
From the Departments o Hematology-Oncology, Pathology and f Laboratory Medicine, and Biostatistics, St Jude Children's Research Hospital, Memphis, TN; and the University of Tennessee, Memphis, College o Medicine, TN. f Submitted February 18, 1993; accepted March 17, 1993. Supported in part by Cancer Center Support CORE Grant P30 CA 21 765 and PO1 CA 20180from the National Cancer Institute, and the American Lebanese Syrian Associated Charities ALSAC ; . Address reprint requests to Ching-Non Pui. MD, St Jude Children's Research Hospital, 332 N. Lauderdale, PO Box 318, Memphis, TN 38101. The publication costs ofthis article were defayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. section I734 solely to indicate this fact. 0 1993 by The American Society o Hematology. f 0006-49 71 93 0.
Storage if you need to store eloxatin before you take it with you to hospital, make sure it is stored in a cool dry place where the temperature does not exceed 30c and enoxacin.
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19 558 of the FVIII A2 domain, around residue 1804 of the FVIII A3 domain, around residue 330 162 in chymotrypsinogen numbering ; of the serine protease domain and the 6894 segment of the FIXa light chain were positioned near to each other 32, 37-39 ; . We also considered interdomain angles within the light chain of FIXa variable angle between EGF1-EGF2 or EGF1-Gla; data not shown ; . In all situations, the two molecules could be positioned closely together despite the presence of mab AW. In the proposed orientation, the serine protease domain of FIXa could interact with the A2 domain of FVIIIa while a short segment around FIXa residues 85-90 ; could contact the A3 domain possibly around residue 1804 ; , whereas EGF1 of FIXa has no direct contact with FVIIIa and enoxaparin.
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Eloxatin may cause nerve damage such as: becoming very sensitive to cold temperatures and cold objects, trouble breathing, swallowing or saying words, jaw tightness, odd feelings in your tongue, chest pressure, pain, tingling, burning, a pins and needles feeling or a numbing of your hands, feet or around your mouth or throat.
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