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The Merck Mectizan Donation Program MDP ; , was launched in 1987, when Merck & Co., Inc. announced that it would donate Mectizan ivermectin ; , its breakthrough medicine for the treatment of onchocerciasis commonly known as "river blindness" ; to all who needed it for as long as necessary. A unique, multi-sectoral partnership was established with the agreement and cooperation of governments in countries where onchocerciasis is endemic, their ministries of health and other national and international stakeholders to ensure appropriate infrastructure, distribution and support. 2005 marked the 18th anniversary of the MDP for the treatment of river blindness. By the end of 2005, Merck had donated over 1.4 billion Mectizan tablets worldwide, reaching more than 45 million people a year in more than 30 countries in Africa, Latin America and Yemen, with more than 460 million cumulative treatments administered since 1987. In addition, more than 95, 000 affected African communities manage the planning and distribution of Mectizan through Community-Directed Treatment. This approach is leading to the integration of other healthcare interventions. Community distributors, specifically trained to distribute Mectizan, are identifying and playing a role in the treatment of other maladies, such as lymphatic filariasis and Vitamin A deficiency. Polio immunization, Guinea worm eradication, and the diagnosis of cataract and trachoma are also being linked to Community-Directed Treatment, a mechanism pioneered through Mectizan distribution. In 1998, the Mectizan Donation Program was expanded to include the elimination of lymphatic filariasis LF ; in African countries and Yemen where onchocerciasis and LF co-exist.
Department of Laboratory Medicine and Pathology, Mayo Clinic and Mayo Foundation, 200 First Street S.W., Rochester, MN 55905. Fax 507-2844542; e-mail klee.george mayo . Received March 3, 1999; accepted May 12, 1999.
| Topical ivermectin for guinea pigsNew Zealand Journal of Zoology, 2004, Vol. 31 The differential efficacy of moxidectin and ivermectin, given by different routes, against an ivermectin-resistant isolate of Cooperia in cattle W. E. POMROY D. M. WEST I. SCOTT Institute for Veterinary, Animal and Biomedical Sciences Massey University Private Bag 11 222 Palmerston North, New Zealand The efficacy of ivermectin I ; and moxidectin M ; given by the oral O ; and parenteral I ; routes against an ivermectin-resistant isolate of Cooperia oncophora were compared. In addition, the efficacy of ivermectin given orally at increasing dose rates was compared. Fifty-four naturally-infected Fresian bulls about 9 months of age were used. For Experiment 1, they were randomly divided into four groups and treated with either ivermectin given orally 0.2 mg kg; IO ; , ivermectin by injection 0.2 mg kg; II ; , moxidectin given orally 0.2 mg kg; MO ; or moxidectin by injection 0.2 mg kg; MI ; . Faecal samples were collected at the time of treatment and 14 days later for estimation of faecal egg counts FEC ; . On each occasion, faeces were also pooled by their relevant group and cultured to produce infective larvae. Efficacy was calculated by comparing pre and posttreatment arithmetic mean FECs. For Experiment 2 the same bulls were randomly divided into five groups 28 days after treatment in Experiment 1 and treated with ivermectin given orally at 0.2 mg kg 1X ; , 0.4 mg kg 2X ; or 0.8 mg kg 4X ; with one group left untreated. FECs were estimated 14 days later. In Experiment 1, after 14 days, the efficacy against Cooperia for IO, II, MO, and MI was 0, 0, 55, and 0%, respectively. The arithmetic mean initial FEC ranged from 584 to 996 eggs g. In Experiment 2, the efficacy against Cooperia calculated by comparing pre- versus post-treatment FEC for 1X, 2X, and 4X was 15, 48, and 82%, respectively. Cooperia larvae were dominant in pre-treatment cultures and were the only genus found post-treatment in both experiments. Moxidectin given orally was more effective than when given by injection but was still far less than fully effective. Both formulations of ivermectin were ineffective at their recommended dose rates. The gradual increase in efficacy for ivermectin when the dose rate was increased suggests it is unlikely that this ivermectin-resistance is inherited as a dominant trait.
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All the evidence shows that patients who take part in clinical trials do better than those who do not. So why is there still such a shortage of recruits? Clare Wareing, a consultant on designing and conducting clinical trials with experimental cancer therapies has spent the last two years researching the use of the Internet to facilitate clinical trial participation in Europe. Here she looks at some of the reasons participation in trials remains so low, and argues that the Internet could help provide a solution and kaletra.
Table 5.1 below lists all entries in the SDP database of the AP defined by this profile. The `Status' column indicates whether the presence of this field is mandatory or optional. The codes assigned to the mnemonics used in the `Value' column and the codes assigned to the attribute identifiers can be found in the Bluetooth Assigned Numbers database. : bluetooth assignednumbers.
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He International Food Policy Research Institute IFPRI ; was established in 1975 to identify and analyze alternative na tional and international strategies and policies for meeting food needs of the developing world on a sustainable basis, with particular emphasis on low-income countries and on the poorer groups in those countries. While the research effort is geared to the precise objective of contributing to the reduction of hunger and malnutrition, the factors involved are many and wide-ranging, requiring analysis of underlying processes and extending beyond a narrowly defined food sector. The Institute's research program reflects worldwide collaboration with governments and private and public institutions interested in increasing food production and improving the equity of its distribution. Research results are disseminated to policymakers, opinion formers, administrators, policy analysts, researchers, and others concerned with national and international food and agricultural policy and kato.
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Cato Lea & Febiger Bantam Books A . Maloine et Fils, diteurs The Julian Press, Inc. Doubleday & Company, Inc. Stewart, Tabori & Chang Lea & Febiger F. A . Davis Company Budlong Press Company The Body Press PennWalt Corporation Editorial Labor, Sociedad Annima Editorial Labor, Sociedad Annima Book Division Spring House American Cancer Society W. B. Saunders Company W. B. Saunders Company.
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Stimpfl T.1, Erdmann F.2, Krause H.3, Krner L.4, Lusthof K.J.5, Reiter A.6, Rochholz G.7, Schneider E. 8, Teske J.9, Vycudilik W.1 and Weller J.P.9 Department of Forensic Medicine, Sensengasse 2, A 1090 Vienna, Austria Institute of Legal Medicine, Frankfurterstr. 58, D 35392 Giessen, Germany 3 Flugmedizinisches Institut der Luftwaffe, Postfach 1264 KFL, D 82242 Frstenfeldbruck, Germany 4 Institute of Legal Medicine, Melatengrtel 60 62, D 50823 Kln, Germany 5 Gerechtelijk Laboratorium, Volmerlaan 17, NL 2288 GD Rijswijk, The Netherlands 6 Institute of Legal Medicine, Kahlhorststr. 31-35, D 23562 Lbeck, Germany 7 Institute of Legal Medicine, Arnold-Hellerstr. 12, D 24105 Kiel, Germany 8 Landeskriminalamt Baden-Wrttemberg, Taubenheimstr. 85, D70372 Stuttgart, Germany 9 Institute of Legal Medicine, Carl-Neuberg Str. 1, D 30625 Hannover, Germany.
ACE Inhibitors: caution in patients on ACE inhibitors may diminish the antihypertensive effect. Lithium: monitoring of serum concentration of lithium advisable. Fluconazole and ketoconazole: dose reduction recommended in these patients Anticoagulants: therapy should be monitored; expect an increase of INR with warfarin and keppra.
1 Giustina A, Barkan A, Casanueva FF, Cavagnini F, Frohman L, Ho K, Veldhuis J, Wass J, Von Werder K & Melmed S. Criteria for cure of acromegaly: a consensus statement. Journal of Clinical Endocrinology and Metabolism 2000 85 526 Trainer PJ. Editorial. Acromegaly consensus, what consensus? Journal of Clinical Endocrinology and Metabolism 2002 87 35343536. Tulipano G, Bonfanti C, Milani G, Billeci B, Bollati A, Cozzi R, Maira G, Murphy WA, Poiesi C, Turazzi S & Giustina A. Differential inhibition of growth hormone secretion by analogs selective for somatostatin receptors subtypes 2 and 5 in human growth-hormone-secreting adenoma cells in vitro. Neuroendocrinology 2001 73 344351. Cozzi R, Attanasio M, Montini M, Pagani G, Lasio G, Lodrini S, Barausse M, Albizzi M, Dallabonzana D & Pedroncelli AM. Fouryear treatment with octreotide-long-acting repeatable in 110 acromegalic patients: predictive value of short term results? Journal of Clinical Endocrinology and Metabolism 2003 88 30903098. Amato G, Mazziotti G, Rotondi M, Iorio S, Doga M, Sorvillo F, Manganella G, Di Salle F, Giustina A & Carella C. Long-term effects of lanreotide SR and octreotide LAR on tumor shrinkage and GH hypersecretion in patients with previously untreated acromegaly. Clinical Endocrinology 2002 56 65 Trainer PJ, Drake WM, Katznelson L, Freda PU, Herman-Bonert V, van der Lely AJ, Dimaraki EV, Stewart PM, Friend KE, Vance ML, Besser GM, Scarlett JA, Thorner MO, Parkinson C, Klibanski A, Powell JS, Barkan AL, Sheppard MC, Malsonado M, Rose DR, Clemmons DR, Johannsson G, Bengtsson BA, Stavrou S, Kleinberg DL, Cook DM, Phillips LS, Bidlingmaier M, Strasburger CJ, Hackett S, Zib K, Bennett WF & Davis RJ. Treatment of acromegaly with the growth-hormone receptor antagonist pegvisomant. New England Journal of Medicine 2000 342 11711177. Giustina A, Casanueva FF, Cavagnini F, Chanson P, Clemmons D, Frohman LA, Gaillard R, Ho K, Jaquet P, Kleinberg DL, Lamberts SW, Lombardi G, Sheppard M, Strasburger CJ, Vance ML, Wass JA & Melmed S. The Pituitary Society and the European Neuroendocrine Association. Diagnosis and treatment of acromegaly complications. Journal of Endocrinological Investigations 2003 26 12421247. Melmed S, Casanueva FF, Cavagnini F, Chanson P, Frohman L, Grossman A, Ho K, Kleinberg D, Lamberts S, Laws E, Lombardi G, Vance ML, Werder KV, Wass J & Giustina A. Acromegaly Treatment Consensus Workshop Participants. Guidelines for acromegaly management. Journal of Clinical Endocrinology and Metabolism 2002 87 4054 and ivermectin.
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