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Have you lost any weight lately?" "No, actually I might be a bit heavier since Christmas . with the cooking and baking it is hard to stay thin." "So you are pretty healthy otherwise?" "Yes, I can't complain. I have a bit of back pain and my ankles swell up here and there but I have no complaints." "No past history of heart disease?" "No" "Stroke or seizures?" "No." "Diabetes or high blood pressure?" "No, dear." I was getting to the end of my rope. I had absolutely no idea what was wrong with Mrs. G, and her surprised looks didn't help. I decided to try another strategy. "Mrs. G, do you live alone?" "Yes, since my husband died four years ago." "And do you live in a house, or an apartment?" "A house, dear." "And is your house well lit?" Now she looked at me as had just stepped out of a spaceship with two antennae sticking out of my head. "Eh, well I guess it is, yes. Why do you ask?" "I just want to figure out why you keep dropping like that." Now she looked at me with her mouth open. She seemed ready to say something, but desisted. I kept going. "Do you have carpeting in your home, Mrs. G?" "Yes." At last, a yes. I knew I was getting close. "And have you ever slipped on the loose carpet?" "No, dear, the carpet is glued to the floor." "Glued to the floor. I see. What medications do you use, Mrs. G." "Oh, just the little white pills for the back pain and Metamucil for . you know.
STUDY 1. Randomized, double-blind phase 3 clinical trial conducted at 19 US centers screened over 1400 smokers mean age 43; mean years of smoking 24; mean number of cigarettes smoked per day 21 ; . The great majority had made at least one prior attempt to quit. All received brief counseling and were followed periodically throughout the trial. 2. Subjects were generally healthy. Exclusion criteria included a number of physical and psychiatric diseases. Thirty percent of individuals screened for the study were excluded. 3. After exclusions, 1025 smokers were randomized to: 1 ; varenicline titrated to 1 mg twice daily, 2 ; bupropion SR titrated to 150 mg twice daily, or 3 ; placebo. 4. Subjects were advised to take the first dose on day one, and set the smoking cessation date on day 8. Active therapy lasted 12 weeks, with subsequent 40 weeks of non-drug follow-up. 5. Determined continuous abstinence for weeks 9 through 52 verified by exhaled carbon monoxide.
MM, Nie G, Weksberg R, Withers S, Quercia N, Teebi AS, Teshima I. Detecting rearrangements in children using subtelomeric FISH and SKY. J Med Genet 2002; 107 : 267274. van Karnebeek CDM, Koevoets C, Sluijter S, Bijlsma EK, Smeets DFMC, Redeker EJ, Hennekam RCM, Hoovers JMN. Prospective screening for subtelomeric rearrangements in children with mental retardation of unknown aetiology: the Amsterdam experience. J Med Genet 2002; 39 : 546-553. Tonk VS, Wyandt HE, Huang X, Patel N, Morgan DL, Kukolich M, Lockhart LH, Velgaleti GVN. Disease associated balanced chromosome rearrangements DBCR ; : report of two new cases. Ann Genet 2003; 46 : 37-43. Jalal SM, Harwood AR, Sekhon GS, Lorentz CP, Ketterling RP, Babovic-Vuksanovic D, Meyer RG, Ensenauer R, Anderson MH, Michels VV. Utility of subtelomeric fluorescent DNA probes for detection of chromosome anomalies in 425 patients. Genet Med 2003; 5 : 28-34. Barber JCK, Joyce CA, Collinson MN, Nicholson JC, Willatt LR, Dyson HM, Bateman MS, Green AJ, Yates JRW, Dennis NR. Duplication of 8p23.1: a cytogenetic anomaly with no established clinical significance. J Med Genet 1998; 35 : 491-496. Barber JCK, Reed CJ, Dahoun SP, Joyce CA. Amplification of a pseudogene cassette underlies euchromatic variation of 16p at the cytogenetic level. Hum Genet 1999; 104: 211-218. Gardner RJM, Sutherland GR. Chromosome abnormalities and genetic counseling. Oxford University Press, Oxford. 1996. Harwood A, Anderson M, Jalal SM. Technical comparison of two commercially available telomere specific probe set. J Assoc Genet Tech 2001; 27 : 132-134. Jalal SM, Harwood AR, Anderson MH, Sekhon GS, Ketterling RP, Michels VV. Analysis by telomere specific FISH probes of 191 karyotypically normal patients with nonspecific dysmorphic features or developmental delay, or history of multiple miscarriages. J Hum Genet 2001; 69 : 333. Fan Y-S, Zhang Y, Speevak M, Farrell S, Jung JH, Siu VM. Detection of submicroscopic aberrations in patients with unexplained mental retardation by fluorescence in situ hybridization using multiple subtelomeric probes. Genet Med 2001; 3 : 416-421. Macina RA, Negorev DG, Spais C, Ruthig LA, Hu X-L, Riethman HC. Sequence organization of the human chromosome 2q telomere. Hum Mol Genet 1994; 3 : 1847-1853. Wolff DJ, Clifton K, Karr C, Charles J. Pilot assessment of the subtelomeric regions of children with autism: Detection of a 2q deletion. Genet Med 2002; 4 : 10-14. Buxbaum JD, Silverman JM, Smith CJ, Kilifarski M, Reichert J, Hollander E, Lawlor BA, Fitzgerald M, Greenberg DA, Davis KL. Evidence for a susceptibility gene for autism on chromosome 2 and for genetic heterogeneity. J Hum Genet 2001; 68 : 1514-1520. de Vries BB, White SM, Knight SJ, Regan R, Homfray T, Young ID, Super M, McKeown, Splitt M, Quarrell OWJ, Trainer AH, Niermeijer MF, Malcolm S, Flint J, Hurst JA, Winter RM. Clinical studies on submicroscopic subtelomeric rearrangements: a check list. J Med Genet 2001; 38 : 145-150.
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Experimental details are given under Materials and Methods. Results are the average of duplicate determinations with individual values shown in parentheses. c Heme levels decreased 38% compared with the acetonitrile, NADPH treatment. d The percentage of spectrally-detectable P450 or activity remaining compared to the mean of the acetonitrile, NADPH ; and TA, NADPH ; controls. e Remaining heme levels showed no decrease compared with the acetonitrile, NADPH treatment.
Fig. 8, the application of 10 mM produced a weak excitation in the ON-OFF DS ganglion cell. In this case, the KAinduced excitation was approximately half of the peak predrug ; light-driven levels. In addition, the excitatory effects of KA were short lived and produced a period of reduced light response during washout. Next, GABAA receptors were blocked by the application of 2 mM SR95531. The blockade and methadone
PHARMACY Michael A. Cozzi, Chicago pharmacist license 051-037292 ; placed in refuse to renew status after defaulting on an Illinois Student Assistance loan. Gary J. Lecoque, Rockford pharmacist license 051-288659 ; issued and placed on probation for two years after being disciplined in Missouri. Thomas Lyons, Orland Park pharmacist license 051-029608 ; suspended for 60 days for failing to use good faith in dispensing Stadol, a controlled substance, and hypodermic needles and syringes. Frederick S. McCall, Glenarm pharmacist license 051-028364 ; placed on probation for three years for self-medicating with controlled substances that he diverted from his pharmacy employer. Rxperts, Inc., Morton Grove pharmacy license 058-013440 ; placed on probation for six months after an audit showed substantial discrepancies in the controlled substances inventory and that a pharmacy employee diverted the controlled substances. Walgreens Healthcare Plus, Tempe, AZ pharmacy license 054-013715 ; reprimanded and fined , 500 for practicing as a mail-order pharmacy in Illinois prior to obtaining a license.
The Phase I II study was conducted to ensure 10 evaluable renal cancer patients participants received either a single subcutaneous SC ; injection of 10.6 million international units MIU ; m2 as Proleukin and IL-2 XL 2 weeks apart using a cross-over design ; . Safety, PK, biological activity and lymphocyte subsets were assessed and methazolamide.
In response, the chairman of the BMA's council, Dr Ian Bogle, maintained that "doctors, too, want to see a modernised NHS." But doctors needed to be involved in planning, developing, and implementing the government's strategies. The chairman of the General Practitioners Committee, Dr John Chisholm, called for "evidence based change." He was worried that walk-in centres could destabilise existing primary care and open the floodgates of demand when the money was available to meet it. The prime minister promised the conference that if the Labour party was returned to power there would be "booked appointments" for everyone. The booking system would allow patients to book hospital consultant appointments or admission dates for operations that were convenient to them. This will start next year with booked appointments for patients with cancer and cataracts. And within the next two years people would be able to see an NHS dentist by phoning NHS Direct.
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TREATMENT GROUP PAROXETINE PLACEBO TOTAL NUMBER OF PATIENTS : 81 100.0% 83 PATIENTS WITH CONDITIONS : 50 61.7% 56 CODE LEVEL 1 : PREFERRED TERM N % N % N % NOS 1 1.2 0 0.0 1 0.6 SINUSITIS, OTHER 0 0.0 1 1.2 1 SINUSITIS, NOS 3 3.7 3 TONSILLITIS, ACUTE 1 1.2 0 0.0 1 0.6 UPPER RESP DISORD, OTHER 6 7.4 5 SIGNS, SYMPTOMS, ILL-DEFINED CON: ANOREXIA APNEA CARDIAC MURMURS CONVULSIONS COUGH DEVELOPMENT, ABN DIARRHEA DISTURBANCE, SPEECH DIZZINESS AND GIDDINESS DYSPNEA, OTHER FLATULENCE FLUSHING HEADACHE HYPERHIDROSIS HYPOESTHESIA INCONTINENCE, URINARY INSOMNIA JAUNDICE, UNSPEC MALAISE AND FATIGUE NAUSEA PAIN UNSP, CHEST PAIN, ABDOMINO-PELVIC PAIN, GENERAL RASH OTHER SKIN ERUPTION SYNCOPE AND COLLAPSE 17 0 0 21.0 0.0 0.0 1.2 2.5 1.2 0.0 1.2 3.7 0.0 1.2 14.8 1.2 0.0 1.2 0.0 0.0 0.0 0.0 0.0 4.9 0.0 0.0 0.0 27 1 0.0 0.0 1.2 0.0 1.2 0.0 1.2 19.3 and methimazole.
Rost pleads state-law claims under the California False Claims Act, Cal. Gov't Code 12651 a ; 1 ; - 2 ; , the Delaware False Claims and Reporting Act, 6 Del. Code Ann. tit. 6, 1201 a ; 1 ; 2 ; , the Florida False Claims Act, Fla. Stat. Ann. 68.082 2 ; , the Hawaii False Claims Act, Haw. Rev. Stat. 661-21 a ; , the Illinois Whistleblower Reward and Protection Act, 740 Ill. Comp. Stat. 175 3 a ; 1 ; - the Massachusetts False Claims Law, Mass. Gen. Laws ch. 12, 5B 1 ; - 2 ; , the Nevada False Claims Act, Nev. Rev. Stat. Ann. 357.040 1 ; a ; - b ; , the Tennessee Medicaid False Claims Act, Tenn. Code Ann. 71-5-182 a ; 1 ; , the Texas Medicaid Fraud Prevention Law, Tex. Hum. Res. Code Ann. 36.002, the Virginia Fraud Against Taxpayers Act, Va. Code Ann. 8.01-216.3 A ; 1 ; - 2 ; , and the District of Columbia Procurement Reform Amendment Act, D.C. Code Ann. 2-308.14 a ; 1 ; - 2 ; . -10.
Name: Page 3 Standard Over-the-Counter PRN Medications: The following medications, and or the generic equivalents, are available in the camp Health Center. CROSS OUT any medications that this camper may NOT be given. Otherwise, based on the presenting symptoms, an RN will choose from among these medications for symptomatic relief and methocarbamol.
Government-approved ways, unaware of their limits, and unable to break free even if they gained awareness. He dreamed of fleshy puppets dancing sick, jerking dances--no volition, no sparkle left in their eyes. Eugene had a recurring nightmare in which he sat on his bed at 3: 23 the morning, completely naked except for a Yankee's hat, looking for something in the thesaurus. * "that tae ot gniog uoy era yeh" When the meaning of the sentence finally penetrated Eugene's wandering brain, he turned to the short, fat woman with the hairy mole on her forehead, "You know, " he said, "you'd be a lot easier to understand if you used punctuation." She stared at him for a moment as if he were the one with the mole, then, "tahw" Thinking of genetics, Eugene gathered himself, "on" he muttered, "eerf leef" The woman grabbed three fish sticks from Eugene's plate, and, as he gazed at her wonderingly, she crammed them in her mouth with such force and enthusiasm that her whole fist seemed to enter and exit her mouth so that she looked like she was punching herself in the face. So engrossed was he in this slightly nauseating spectacle that he didn't notice the waitress on the other side of him about to trip on his bag and drop the glass of water she was carrying. The glass slipped off of his tray and Eugene watched it fall to the floor in slow motion. When it didn't shatter, he was surprised that he was surprised because he had known that it was plastic: why would they give him a glass glass, considering the tendency of airplanes to crash, exactly as his flight from Houston to Chicago was? The airplane was.
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Appeared to be conserved in both enzymes Fig. 1A, closed arrow heads ; . The third potential N-glycosylation site was located close to the C-terminus of both enzymes Fig. 1A, open arrow heads ; . A remarkable difference and methotrexate.
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Brands: Clairol Shampoo, Clarion Cosmetics, Clearsil Soap, Colorfast Cosmetics, Covergirl Cosmetics, Crest Dental Care, Head & Shoulders Shampoo, Herbal Essences Shampoo, Max Factor Cosmetics, Metamucil Laxatives, Mum Deodorant, Olay Skin Care, Old Spice Deodorant, Pantene Shampoo, Pert Shampoo, Tampax Feminine Hygiene, Vicks * Cold & Flu, Vidal Sasson Shampoo, Whisper Feminine Hygiene, Zest Soap Ownership Company: Proctor & Gamble Australia Pty Ltd Proctor & Gamble Australia Pty Ltd is a Foreign-owned Wholly-owned Subsidiary, generating revenue of approximately AUS7 million in 2004. Assessments: Criticism: Reputex Social Responsibility Rating B + Low ; : reputex .au ; Other Information: Possible GE ingredients : truefood .au guide2 ; Contact: phone 02 9684 8444 web : pg Parent Company: Proctor & Gamble Company, USA Proctor & Gamble Company is a Foreign-owned Listed Public Company, generating revenue of approximately AUSUS.4 billion in 2004. Assessments: Criticism: Animal Testing : caringconsumer page CompaniesDo ; , Animal Testing : ethicalconsumer magazine buyers 80 crisps ; , Yellow flag for Social : : responsibleshopper basic ?cusip 742718 ; , Boycott Call : IAMScruelty ; , Animal Cruelty : IAMScruelty ; Praise: Fairtrade Products : : globalexchange campaigns fairtrade coffee Millstonevictory ; Other Information: Company Profile - Responsible Shopper : : responsibleshopper basic ? cusip 742718 ; , Company Profile - Knowmore : knowmore index The Procter and Gamble Company ; Contact: phone xxx 513 983 1100 web : pg and metamucil.
NAPSI ; -A new survey reveals that for American women, beauty isn't necessarily on the inside. According to a poll by Harris Interactive, 41 percent of women see their hairstylist three to four times per year, while one in four women has never had her cholesterol checked. Only 13 percent of women view heart disease as a health threat, even though it's the number one killer of women. What many women don't realize is that heart disease is largely preventable, and women can take steps to lower their risk. One easy way to start on a path to a hearthealthy lifestyle is to enroll in the Metamucil 30-Day Difference now through March 2008. Brenda Strong, who plays Mary Alice Young on Desperate Housewives, is partnering with Metamucil to educate women about heart health because of her interest in healthy living and support of heart health education. Beautify Your Heart The 30-Day Difference was created to encourage women to beautify their hearts and start lowering their cholesterol by taking the following simple steps: Create a profile on beautifyyourheart to get tips from the fitness and nutrition experts at Core Performance, a fitness and training center for elite athletes and everyday people. Develop a personalized fitness routine two to three days per week ; using the tools provided on beautifyyourheart . "Proper nutrition and exercise are simple ways to ensure your heart is healthy, " says Dr. Carl L. Tommaso, director of the cardiac catheterization laboratory at Rush North Shore Medical Center in Skokie, Ill. "Though people don't realize it, fiber supplements like Metamucil have been recommended by the American Heart and methylcellulose.
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Frank HA et al. 1979 80 ; administered a mucilagenous hydrophilic colloid bulk laxative Metamucil, ispaghula husk ; to severely burned patients on tube feeding formulae 5, 000 to 6, 000 calories per day ; . The dosage and frequency were adjusted to individual patient needs, but averaged 7 g per litre of liquid formula. Colonic transit time increased. The stools became formed but soft, cohesive but not adhesive. Perianal irritation did not occur. No rebound constipation or obstructive symptoms were encountered. Exact data were not mentioned in the publication. The authors attributed the observed response to the same water binding mechanism that allows these mucilagenous colloids to prevent chronic constipation. Qvitzau S et al. 1988 81 ; included 25 patients with chronic diarrhoea in an open, randomised crossover trial comparing the effect of loperamide with ispaghula and calcium. The dose of loperamide administered was 4 mg initially and 2 mg after each loose stool. Maximal dose was 16 mg day. Ispaghula husk-calcium contained ispaghula husk, CaCO3 and CaHPO4 weight ratio 4: 1: ; The daily dose was 5 g twice a day. Nineteen patients completed both treatments. Before treatment the median number of daily stools was 7 range: 4-13 ; , stool consistency was loose in all, and urgency was present in 16 out of 19 patients. Both treatments halved stool frequency, but with regard to urgency and stool consistency the treatment with ispaghula husk and calcium was significantly better. Urgency was significantly related to order of treatment, indicating that the washout period was too short. A combination of ispaghula husk and calcium seemed to be an effective alternative to convential treatment of chronic diarrhoea. Moreover, a tendency towards a reduced frequency of side effects during treatment with ispaghula husk-calcium was found, although this difference did not reach statistical significance. In a short letter to the Editor, Bobrove 1990 82 ; noticed that psyllium may be helpful, if diarrhoea occurs as a side effect of medicinal products. In a randomised crossover study Lodge N et al. 1995 83 ; investigated the efficacy of codeine phosphate versus ispaghula husk in 10 female patients with gynaecological cancer experiencing diarrhoea during pelvic radiotherapy. Quantitative data were collected from patient diaries and treatment flow-sheets. All five patients in the codeine phosphate arm received adequate control, while the five patients allocated to the ispaghula husk arm were all crossed-over to codeine phosphate with resolution of their diarrhoea. The authors concluded that ispaghula husk, whilst not totally ineffective at controlling diarrhoea induced by pelvic radiotherapy, was significantly less effective than codeine phosphate. Antidiarrhoeal effect in children Smalley JR et al. 1982 29 ; evaluated the use of ispaghula husk Metamucil ; in the management of chronic non specific diarrhoea of childhood CNDC ; . Specific reasons of diarrhoea were excluded. Twenty three children between 6 and 36 months of age with CNDC received unrestricted diet including milk for 1 week, then were treated during the following 2 weeks Metamucil 1 tablespoon twice a day exact amount not mentioned ; if diarrhoea persisted. Ispaghula husk was discontinued for 1 week, and if diarrhoea returned ispaghula husk was used for another 2 weeks. Seven children 30 % ; responded to an unrestricted diet alone. From the 16 remaining children, 13 81 % ; responded during the first 2 weeks of treatment with ispaghula husk. Eleven had total resolution of their diarrhoea, 2 were partial responders. After taking off ispaghula husk for one week, 6 children relapsed but 3 of them did not redevelop symptoms as severe as those they had had initially. All 6 patients responded after another 2-week course of ispaghula husk. Three patients did not respond to either an unrestricted diet or ispaghula husk.
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| Metamucil capsules side effectsPlain radiography NPC view ; although inexpensive is less useful than CT because of the composite nature of the resultant image.21 The absence of abnormal soft tissue swelling and erosion of base of skull should not be taken as conclusive evidence of exclusion of NPC. Instead if the clinical suspicion is strong a CT scan should be arranged, and particularly the base of skull should be assessed fully. CT is definitely a more sensitive means of detecting and delineating this tumour.13 It is especially useful in patients with submucosal tumour and paranasopharyngeal extension which is difficult to be visualized by endoscopy and impossible by plain radiography. Extranasopharyngeal extension of the tumour is present in a high percentage of cases, and it may be the only clue to the presence of the tumour. Moreover, the presence of paranasopharyngeal extension is of great prognostic importance.22 Because of the nonreliance on differential density, magnetic resonance imaging MRI ; has been increasingly utilized for the estimation of the tumour volume and the response to treatment. This disease is prone to spread to the bone which accounts for 40% of distant sites of failure with predilection to the vertebrae and pelvis. We have conducted a prospective study to evaluate the role of pre-treatment bone scan in the detection of subclinical bony metastases of our group of patients in 1985-7. A total of 142 new patients with NPC and no evidence of distant metastases were evaluated for bony metastases with bone scan. Forty-four patients had abnormal scanning and 39 were excluded because of other benign bony conditions. Fourteen patients subsequently developed bony metastases over a follow-up period of 0.2-41 months. In only three patients were the sites of bony metastases corresponding to the original sites of the abnormal scan. In view of the low sensitivity and specificity, we conclude that bone scan should not be routinely used as a base line investigation.23 Bone marrow biopsy is an investigational procedure used extensively in some malignant condition such as lymphoma and small cell lung cancer. Because of the marginal value of bone scan and the propensity of NPC to spread to bone we have evaluated the role of bone marrow biopsy. Twenty-seven new NPC patients with advanced disease had bone trephine biopsy and marrow aspirate evaluated by morphology and immunohistochemical studies for cytokeratin before the commencement of the definitive treatment. All were negative. The median follow-up and methyldopa.
Income eligibility levels have been expanded for pregnant women and infants up to age one. Many pregnant women, who were previously not eligible, may now receive medical assistance. To encourage early prenatal care, Medicaid application procedures for pregnant women have been simplified. Women who are deemed eligible for Medicaid by their LDSS are guaranteed eligibility regardless of income changes, up until the end of the month in with the sixtieth day after the end of the pregnancy occurs and methadone.
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Leaving the viable conidia attached on the bottom of the wells. The conidia were then washed in order to remove the drug and incubated with fresh medium. Finally, growth was detected with an and methysergide.
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Binding domains on the so-called 1 subunit of the L-type Ca2 channel complex and thereby cause channel block 1 ; . Recent biochemical studies, employing photoaffinity labeling, site-directed mutagensis, and chimeric 1 subunit constructs revealed that high affinity binding determinants for these drugs are located close to pore-forming regions of L-type Ca2 channel 1 subunits. Important binding determinants for DHPs and PAAs were identified in transmembrane segments IIIS5, IIIS6, and IVS6 for review, see Refs. 2 and 3 ; . Both classes of drugs directly or indirectly affect Ca2 coordination to the channel's selectivity filter glutamates. It is therefore conceivable that these drugs cause Ca2 channel block by binding to pore-forming regions, thereby altering channel gating and Ca2 ion interaction with the pore for review, see Refs. 2 and 3 ; . Less detailed structural information is available for the BTZ binding domain, which mediates use-dependent Ca2 channel block by diltiazem. BTZ and PAA interaction with the channel is similar in many respects; BTZs and PAAs contain a basic nitrogen essential for activity 4 ; and, unlike for DHPs, Ca2 channel block critically depends on depolarization frequency "use-dependent block" ; . Some early radioligand binding experiments even proposed that PAAs and BTZs compete for the same site 5 ; on the channel. This is supported by the finding that identical amino acid residues in IVS6 are essential for high affinity PAA as well as diltiazem sensitivity 2, 6 ; . On the other hand several lines of evidence suggest that the PAA and BTZ binding domains are not identical; PAAs and BTZs possess a distinct structure-activity relationship for blocking 4 ; and they access their binding domains from opposite sides PAAs, the cytoplasmic side; BTZs, the extracellular side ; of the channel 7 ; . In extensive analysis combining information from alanine-scanning mutagenesis and radioligand binding we provide further insight into the molecular architecture of the BTZ binding domain of L-type Ca2 channels. In particular we identified two amino acid residues in transmembrane segment IIIS6 which affect diltiazem sensitivity by different mechanisms and provide evidence for a steric interaction between the BTZ and DHP binding domain.
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