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A national multi-site project sponsored by Pediatric Orthopaedic Society of North America. Investigators: Kevin Walker, MD, PI, Stephen Sundberg, M.D., Deborah Quanbeck, M.D., Lael M. Luedtke, M.D., Steven Koop, M.D., Tom Novacheck, M.D., James Gage, M.D. and Stephen England, M.D.
This research was supported by Roche Products Ltd. Dr Cooper and Dr Brankin have served as speakers, consultants and advisory board members for Roche Products Ltd and GlaxoSmithKline, and have received research funding from Roche Products Ltd. Dr Drake is an employee of Roche Products Ltd.
NAPSA ; --A new, once-daily medication is available to help adults, adolescents and children with Attention-Deficit Hyperactivity Disorder ADHD ; . The U.S. Food and Drug Administration FDA ; has approved Focalin XRTM dexmethylphenidate HCl ; extended-release capsules, a medication that effectively manages ADHD symptoms quickly with a single morning dose. "Focalin XR provides a new treatment option for adults, adolescents and children to address the many difficult symptoms of ADHD, " said Thomas Spencer, M.D., Associate Professor of Psychiatry, Harvard Medical School and Assistant Director of the Pediatric Psychopharmacology Research Program at Massachusetts General Hospital. "Focalin XR provides patients with a treatment that starts working quickly to alleviate symptoms with the advantage of a once-daily dose." In adults and children, the core symptoms of ADHD are inattention, impulsivity and hyperactivity; however, in adults symptoms of hyperactivity often subside with maturity or may manifest differently. ADHD is one of the most common psychiatric disorders of childhood and is estimated to affect five to seven percent of children. Many children with ADHD will continue to experience symptoms into adulthood. ADHD is estimated to affect approximately four percent of the adult population. but I actually noticed the difference right away--the day he started taking it, " Robin recalled. "It was a placebo-controlled trial, so we weren't told if he was taking Focalin XR or a sugar pill, but I saw such an improvement in his symptoms that I knew that he was getting the medicine." Soon she began to notice improvements in all aspects of his life. "He was doing better at work. He was getting home on time. He was spending quality time with me. He enrolled in a college course. He's gone back to college and now he's getting A's, " she said. "It's just been wonderful." The approval of Focalin XR for the treatment of ADHD was based on efficacy and safety data from clinical trials involving approximately 320 adults, adolescents and children diagnosed with ADHD. Results indicated that Focalin XR was statistically superior to placebo. Focalin XR was generally well tolerated. There were no significant changes in patient weight or vital signs, such as sitting pulse or sitting blood pressure, in adults or children. The most common side effects in adults and children include decreased appetite, headache, dyspepsia, anxiety, insomnia, feeling jittery and anorexia. For more information about ADHD, visit ADHDInfo . For more information about Focalin XR, visit Focalin XR.
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Wallac Plate Shake 1296-004, Wallac OY, Turku, Finland ; until complete dissolution of formazan derivatives, color absorbance was measured spectrophotometrically at 450 630 nm Elx808, Bio-Tek Instruments, Winooski VT, USA ; . Background absorbance was measured for each microtitration plate from five conidia-free wells processed in the same way as the inoculated wells. The XTT absorbance values after subtraction of background absorbance quantify the amount of fungal growth at each drug concentration and can be used as a measure of.
10 see lortab elixir pediatric dosing 1 for certain generic company first generics upon reformulation.
Within the market structure, once a market structure is identified, pricing techniques will form an integral part of this discussion. Importantly, issues such as cost plus pricing, incremental pricing, two-part tariffs, bundling, tying, skimming, price lining, value pricing and other modern techniques of pricing practice will be dealt with in detail in the next chapter and pegasys.
CNS malignancies, melanoma, nonsmall-cell lung cancer, and colon, ovarian, renal, and prostate carcinomas.2 Preclinical antitumor activity of proteasome inhibitors has also been observed in leukemias and lymphomas and childhood tumors such as neuroblastoma, 3, 4 rhabdomyosarcoma, 5 and Ewing's sarcoma.6 The pattern of growth inhibition and cytotoxic activity of bortezomib is unique compared with other anticancer agents, suggesting a novel mechanism of cytotoxicity.7 Two bortezomib dosing schedules have been evaluated in adult phase I clinical trials: a twice weekly for 4 weeks schedule followed by a 2-week rest, and a twice weekly for 2 weeks schedule followed by a 2-week rest. The maximumtolerated dose MTD ; for the twice weekly for 4 weeks schedule was 1.04 mg m2. Dose-limiting toxicities at higher dose levels 1.20 or 1.38 mg m2 ; included thrombocytopenia, hyponatremia, hypokalemia, fatigue, and malaise.8 Other serious adverse events included one episode of postural hypotension and one hypersensitivity reaction.8 Antitumor activity was observed in patients with refractory multiple myeloma and non-Hodgkin's lymphoma.8 The MTD for the twice weekly for 2 weeks schedule was 1.56 mg m2.9 The dose-limiting toxicities on this schedule were diarrhea and sensory neurotoxicity. There was no doselimiting hematologic toxicity.9 There was one objective response in a patient with nonsmall-cell lung carcinoma.9 The antitumor activity of bortezomib was confirmed in two recently completed phase II clinical trials in adults with multiple myeloma.10 The overall objective response rate after bortezomib administration was 33% in a heavily pretreated population. This high level of antitumor activity resulted in recent US Food and Drug Administration approval of bortezomib for third-line treatment in adults with multiple myeloma. A randomized phase III trial of bortezomib versus high-dose dexamethasone in patients with multiple myeloma is in progress. This report presents the results of a phase I trial and pharmacodynamic study of bortezomib, given twice weekly for 2 consecutive weeks every 21 days, in pediatric patients with refractory solid tumors. The objectives of this study were to identify the optimal bortezomib dose for phase II pediatric trials, to determine the incidence and severity of toxicities associated with bortezomib administration, and to evaluate inhibition of the 20S proteasome after bortezomib administration.
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UTSA's Institute of Texan Cultures, 094-0128. Students, principal, and teacher posed outside the Macdona School, ca.1915, Macdona, Texas. Photograph shows students with principal and teacher posed outside their schoolhouse. Names provided by Emma Marbach Koehler and Maggie Barker Weir. Third row: third from left, Teckla Weilbacher Nentwich, principal Charles A. Ridout, teacher Annie Bywaters and principal's daughter. Second row: sixth from left, Sadie Ridout, eighth from left, Otelia Jackel Schirmer, Clara Zeinert Halbardier. Front row: second from left, Albert "Cotton" Schirmer. On bicycle: Claude Ballew. On stool: Gus Neumann. Standing on chair: Frank Zeinert. The schoolhouse had two large rooms joined by a long hall which had shelves for lunch buckets and hooks for coats. Courtesy of Bobby Zeinert. San Antonio Light Collection, UTSA's Institute of Texan Cultures, L-3714-I. Physiotherapist Gladys Wright assists Gale Singleton at school for orthopedically handicapped. Photographed in San Antonio, Texas, March 25, 1949. Picture caption: "Gale Singleton, 6, practices walking. Physiotherapist Gladys Wright R ; supervises Training." Article: "Eloise Japhet school for the orthopedically handicapped is the only one of its kind in Texas. Under supervision of the San Antonio Independent School District, it is like any other public school, except all of its students have some handicap to overcome. It opened with 30 children four years ago on a legislative grant.Beside regular classroom subjects, the school has a physiotherapist. She aids the children in partially overcoming their handicaps ."-Article. Courtesy of the Hearst Corporation. San Antonio Light Collection, UTSA's Institute of Texan Cultures, L-3830-H. Gerald Smith plays violin as his instructor, Alton H. Jung, turns music page. Photographed in San Antonio, Texas, September 30, 1949. Picture caption: "Alton H. Jung instructs Gerald Smith on the violin Student at Emerson Junior High School takes advantage of new music set up." Article: "Students of the San Antonio public schools are going around these days with songs in their hearts. The new set-up calls for every student in the first six grades to get musical instruction." Courtesy of the Hearst Corporation. From the collections of the Texas Dallas History and Archives Division, Dallas Public Library. Teachers and students look at the Marion Butts Historical Photo Exhibit at Erasmo Seguin School and pegfilgrastim.
Zurovac D, and Rowe AK. Quality of Treatment for Febrile Illness Among Children at Outpatient Facilities in SubSaharan Africa. 2006; 100 4 ; : 28396. : ncbi.nlm.nih. gov entrez query.fcgi?cmd retrieve&db pubmed&list uids 16762109&dopt abstract.
Bergen's total area 465.3 km2 515 Population per km2 Population pr.31 12-2005 ; 242.158 Currency: Norwegian Kroner NOK ; pr feb. 2007 EURO 8.2 Number of hotel beds in Bergen approx. 8000 Minimum temperature in 2006 -8, 3 C Maximum temperature in 2006 28, 0 C Normal rainfall per year 1961-1990 ; 2.250 mm Average temperatures 1961-1990 ; January 2, 7 C July February 3, 0 C August March 4, 9 C September April 8.0 C October May 12, 9 C November June 15, 1 C December Sunlight rise 1 January 1 February 1 March 1 April 1 May 1 June and fall ; 09.26-15.12 08.34-16.24 07.15-17.41 July 1 August 1 September 1 October 1 November 1 December 16, 6 C 16, 3 C 13, 3 C 9, 8 C 5, 03.47-22.51 04.49-21.52 Direct flights to Bergen from the following international cities: Alicante Amsterdam Aberdeen Berlin-Schnefeld Billund Copenhagen Dubrovnik Dsseldorf Edinburgh London-Gatwick London-Stansted Malaga Mnchen Murcia Newcastle Nice Paris-Orly Prague Reykjarvik Riga Salzburg Stockholm Warszawa Direct flights to Bergen from the following domestic cities: Bod Frde Flor Haugesund Kristiansand Kristiansund Molde Notodden Oslo Sandane Sandefjord Skien Sogndal Stavanger Troms Trondheim lesund Distances to other cities in Norway: Frde 186 km North Cape Geilo 233 km Oslo Haugesund 117 km Stavanger Haukeligrend 256 km Trondheim Kristiansand 493 km Voss Molde 453 km lesund National Holidays 2007 New Year's Day: 1 January Palm Sunday: 1 April Maundy Thursday: 5 April Good Friday: 6 April Easter Sunday: 8 April Easter Monday: 9 April Labour day: 1 May 2 368 km 478 km 178 km 657 km 99 km 375 km and pegvisomant.
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Effects of midazolam in the anaesthetized patient with coronary artery disease. Acta Anaesthesiol Scand 27: 299 302. May CN, Ham IW, Heslop KE, Stone FA and Mathias CJ 1988 ; Intravenous morphine causes hypertension, hyperglycaemia and increases sympatho-adrenal outflow in conscious rabbits. Clin Sci Lond ; 75: 7177. McQuay HJ 1991 ; Opioid clinical pharmacology and routes of administration. Br Med Bull 47: 703717. Murray MJ and Plevak DJ 1994 ; Analgesia in the critical ill patient. New Horiz 2: 56 63. Nanoff C, Mitterauer T, Roka F, Hohenegger M and Freissmuth M 1995 ; Species differences in A1-adenosine receptor-G protein coupling: Identification of a membrane protein which stabilizes the association of the receptor G protein complex. Mol Pharmacol 48: 806 817. Reisine T and Pasternak G 1996 ; Opioid analgesics and antagonists, in The Pharmacological Basis of Therapeutics, 9th ed. Hardman JG, Limbird LE, Molinoff PB, Ruddon RW and Gilman AG eds ; pp 521555, McGraw-Hill, New York. Ritschel WA 1986 ; Handbook of Basic Pharmacokinetics, p 387, Drug Intelligence Publications Inc., Hamilton, IL. Ruffolo RR, Spradlin TA, Pollock GD, Waddell JE and Murphy PJ 1981 ; Alpha and beta adrenergic effects of the stereoisomers of dobutamine. J Pharmacol Exp Ther 219: 447 452. Schwartz DA and Horwitz LD 1975 ; Effects of ketamine on left ventricular filling performance. J Pharmacol Exp Ther 194: 410 414. Schwartz PH, Eldadah MK and Newth CJ 1991 ; The pharmacokinetics of dobutamine in pediatric intensive care unit patients. Drug Metab Dispos 19: 614 619. Shoemaker WC, Appel PL and Kram HB 1991 ; Oxygen transport measurements to evaluate tissue perfusion and titrate therapy: Dobutamine and dopamine effects. Crit Care Med 19: 672 688. Shoemaker WC, Elwyn DH, Levin H and Rosen AL 1974 ; Early prediction of death and survival in postoperative patients in circulatory shock by nonparametric analysis of cardiopulmonary variables. Crit Care Med 2: 317325. Shoemaker WC 1995 ; Diagnosis and treatment of the shock syndromes, in Textbook of Critical Care, 3rd ed. Shoemaker WC, Ayres SM, Grenvik A and Holbrook PR eds ; pp 85102, W B Saunders Company, Philadelphia. Stanley TH and Webster LR 1978 ; Anesthetic requirements and cardiovascular effects of fentanyl-oxygen and fentanyl-diazepam-oxygen anesthesia in man. Anesth Analg 57: 411 416. Steltzer H, Krafft P, Fridrich P, Hiesmayr M and Hammerle AF 1994 ; Right ventricular function and oxygen transport patterns in patients with acute respiratory distress syndrome. Anaesthesia 49: 1039 1045. Thomson IR, Bergstrom RG, Rosenbloom M and Meatherall RC 1988 ; Premedication and high-dose fentanyl anesthesia for myocardial revascularization: A comparison of lorazepam versus morphine-scopolamine. Anesthesiology 68: 194 200. Tomichek RC, Rosow CE, Philbin DM, Moss J, Teplick RS and Schneider RC 1983 ; Diazepam-fentanyl interaction - hemodynamic and hormonal effects in coronary artery surgery. Anesth Analg 62: 881 884. Tuttle RR and Mils J 1975 ; Dobutamine. Development of a new catecholamine to selectively increase cardiac contractility. Circ Res 36: 185196. Vargish T, Beamer KC, Daly T and Head R 1987a ; Myocardial opiate receptor activity is stereospecific, independent of muscarinic receptor antagonism and may play a role in depressing cardiac function. Surgery 102: 171177. Vargish T, Beamer KC, Daly T and Riggs TR 1987b ; Morphine sulfate depression of cardiac function is attenuated by opiate receptor antagonism with naloxone. Circ Shock 23: 189 195.
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See Pasche B Kakolyris S, see Georgoulias V Kalaycio M, see Feldman EJ Kalble T, see Lehmann J Kaldjian EP, see Campos S Kalemkerian G. Trastuzumab in the Treatment of Advanced NonSmallCell Lung Cancer: Is There a Role? correspondence ; , 1325 Kalemkerian GP. Commentary on "Unrealistic Expectations, " 4233 Kalemkerian GP. Is Collusion Necessary? A Commentary on Necessary Collusion, 3153 Kalidas M, see Chang JC Kalifa C, see Entz-Werle N see Oyharcabal-Bourden V Kalimuthu SG, see Hussein MAH Kallioniemi A, see Honrado E Kalnitskiy M, see Ryan QC Kalra K, see Edelman MJ Kaltenbach T, see Soetikno R Kalva SP, see Willett CG Kam AW, see Pingpank JF Kam BL, see Kwekkeboom DJ Kamijo T, see Igarashi S Kamikawa S, Inui A. Pediatric Malignancies. Craniopharyngioma in a 4-Year-Old Girl: Neuroendoscopic Diagnosis, 4793 Kaminski MS, see Fisher RI Kaminski MS, Radford JA, Gregory SA, Leonard JP, Knox SJ, Kroll S, Wahl RL. Re-Treatment With I-131 Tositumomab in Patients with NonHodgkin's Lymphoma Who Had Previously Responded to I-131 Tositumomab, 7985 Kaminsky DB, see Austin RM Kammoun L, see Abdelkefi A Kammula US, see Attia P see Dudley ME Kammula US, Coit DG. In Reply correspondence ; , 3864 Kamps WA, see Nijhuis CO see Pession A Kanakura Y, see Sakane-Ishikawa E Kanamaru A, see Sakane-Ishikawa E Kanayama N, see Matsuzaki H Kanazawa S, Muramatsu M, Kinoshita Y, Yamaguchi K, Nomura S. Gefitinib Has the Potential of Activating Cell Immunity Against Malignant Cells correspondence ; , 3865 Kanazawa T, see Watanabe T Kane CJ, see Freedland SJ Kaneko T, see Igarashi S Kang JC, Wanek LA, Essner R, Faries MB, Foshag LJ, Morton DL. Sentinel Lymphadenectomy Does Not Increase the Incidence of In-Transit Metastases in Primary Melanoma, 4764 Kang S, Badger J Kang WK, see Rhee J-Y Kantarjian H, see Bueso-Ramos C see Cortes J see Keating MJ see Wierda W Kantarjian HM, see Issa J-PJ Kanz L, see Lengerke C Kapadia D, Fong L. CTLA-4 Blockade: Autoimmunity As Treatment editorial ; , 8926 Kaplan PA, see Floyd JD see Sachs BA Karagorgis P, see Athanassiou H Karakiewicz PI, see Lotan Y Karim R, see Lim S-T see Lim ST and pemetrexed.
Refereeces: 1. Bressler B, Friedel RO: A comparison between chlorpromazine and thiothixene in a Veterans Administration hospital population. Psychosomatics 1971 12: 275-277. DiMascio A, Demirgian E: Ste of the activating properties of thiothixene. P5$IlOSOIInaIicS 1972; 13: 1O5-108. DiMascio A, Dernirgian Jobtraining in the rehabilitation ofthe chronic schizophrenic. Presented as a Scientific ExhibitatThe American PsychIatric Association. Washington, DC, May 3-6, 1971. 4. Goldstein B, Weiner 0, Banas F: Clinical evaluation ofthiothixene in chronic ambulatory schizophrenic patients, in Lefnmann HE, Ban TA eds ; : The Thxanthenes: Modem Problems ofPfsarmacc# syvhiatry Basal, Switzerland, S. Karger, 1969, vol 2, pp 45-52. 5. Dillenkoffer RL, Gallant DM, George RB, et at: ElectrocardiographIc evaluation of schizophrenic patients: A double-blind comparison. Presented as a Scientific Exhibit at The 125th Annual Meeting of the American Psychiatric Association, Dallas, May 1-4, 1972. 6. Data available on request from Roerig. BRIEF SUMMARY OF PRESCRIBING INFORMATION Nevanet tfdothlzsne ; Capsules: 1 mg, 2 mg, 5 mg, 10 mg, 20 mg thlothlx.ns hydreclikirlde ; Concentrate: 5 mg mI, Intramuscular 2 mg mI, 5 mWmI IndIcatIons: Navane is effective in the management of manifestations of psychotic disorders. Navane has not been evaluated in the managementof behavioral complications in patients with mental retardation. Costraledleatlons: Contraindicated in patients with circulatory collapse, comatose states, central nervous system depression due to any cause, and blood dyscrasias. Contraindicated in individuals who have shown hypersensitivity to the drug. It is not known whether there is a cross-sensitivity between the thioxanthenes and the phenothiazine derivatives, but the possibility should be considered. WarnIngs: Tardive Dyskinesia-Tardive dyskinesia, a syndrome consisting of potentially irreversible, involuntary, dyskinetic movements may develop in patients treated with neuroleptic antipsychotic ; drugs. Althoughthe prevalence ofthe syndrome appears to be highest among the elderly, especially elderly women, it is impossible to rely upon prevalence estimates to predict, atthe inception of neuroleptictreatment, which patients are likely to develop the syndrome. Whether neuroleptic drug products differ in their potential to cause tardive dyskinesia is unknown. Both the risk of developing the syndrome and the likelihood that it will become irreversible are believed to increase as the duration oftreatment and the total cumulative dose of neuroleptic drugs administered to the patient increase. However, the syndrome can develop, although much less commonly, after relatively brief treatment periods at low doses. There is no known treatment for established ises of tardive dyskinesia, although the syndrome may remit, partially or completely, if neuroleptic treatment is withdrawn. Neuroleptic treatment, itself, however, may suppress or partially suppress ; the signs and symptoms of the syndrome and thereby may possibly mask the underlying disease process. The effect that symptomatic suppression has upon the long-term course ofthe syndrome is unknown. Given these considerations, neuroseptics should be prescribed in a manner that is most likely to minimize the occurrence of tardive dyskinesia. Chronic neuroleptic treatment should generally be reserved for patients who sufferfrom a chronic illness that, 1 ; is known to respond to neuroleptic drugs, and, 2 ; for whom alternative, equally effective, but potentially less harmful treatments are notavailable or appropriate. In patients who do require chronic treatment, the smallest dose and the shortest duration of treatment producing a satisfactory clinical response should be sought. The need for continued treatment should be reassessed periodically. If signs and symptoms of tardive dyskinesia appear in a patient on neuroleptics, drug discontinuation should be considered. However, some patients may require treatment despite the presence of the syndrome. Forfurther information about the description of tardive dyskinesia and its clinical detection, please refer to Information for Patients in the Precautions section, and to the Adverse Reactions section. ; Neuroleptic Malignant Syndrome NMS ; -A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome NMS ; has been reported in association with antipsychotic drugs. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability irregular pulse or blood pressure, tachycardia, diaphoresis. and cardiac dysrhythimas ; . The diagnostic evaluation of patients with this syndrome is complicated. In arriving at a diagnosis, it is important to identify cases wherethe clinical presentation includes both serious medical illness e.g. , pneumonia, systemic infection, etc. ; and untreated or inadequately treated extrapyramidal signs and symptoms EPS ; . Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever and primary central nervous system CNS ; pathology. The management of NMS should include 1 ; immediate discontinuation of antipsychotic drugs and other drugs notessentiatto concurrenttherapy, 2 ; intensive symptomatictreatmentand medical monitoring, and 3 ; treatment ofany concomitant serious medical problems forwhich specifictreatmentsareavailable. There is no general agreement about specific pharmacological treatment regimens for uncomplicated NMS. If a patient requires antipsychotic drug treatment after recovery from NMS, the potential reintroduction of drug therapy should be carefully considered. The patient should be carefully monitored, since recurrences of NMS have been reported. Usage in Pregnancy-Safe use of Navane during pregnancy has not been established. Therefore, this drug should be given to pregnant patients only when, in the ludgmentofthe physician, the expected benefits from the treatment exceed the possible risks to mother and fetus. Animal reproduction studies and clinical experience to date have not demonstrated any teratogenic effects. In the animal reproduction studies with Navane, there was some decrease in conception rate and litter size, and an increase in resorption rate in rats and rabbits, changes which have been similarly reported with other psychotropic agents. After repeated oral administration of Navane to rats 5 to 15 mg kg day ; , rabbits 3 to 50 mg kg day ; , and monkeys 1 to 3 mg kg day ; before and during gestation, no teratogenic effects were seen. See Precautions. ; Usage in Children-The use of Navane in children under 12 years of age is not recommended because safety and efficacy in the pediatric age group have not been established. As is true with many CNS drugs, Navane may impair the mental and or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery, especially during thefirst few days oftherapy. Therefore, the patient should be cautioned accordingly. As in the case of other CNS-acting drugs, patients receiving Navane should be cautioned about the possible additive effects which may include hypotension ; with CNS depressants and with alcohol. PrecautIons: An antiemetic effect was observed in animal studies with Navane; since this effect may also occur in man, it is possible that Navane may mask signs of overdosage of toxic drugs and may obscure conditions such as intestinal obstruction and brain tumor. In consideration of the known capability of Navane and certain other psychotropic drugs to precipitate convulsions, extreme caution should be used in patients with a history of convulsive disorders or those in a state of alcohol withdrawal since it may lower the convulsive threshold. Although Navane potentiates the actions of the barbiturates, the dosage ofthe anticonvutsant therapy should not be reduced when Navane is administered concurrentty. Caution as well as careful adjustment of the dosage is indicated when Navane is used in conjunction with other CNS depressants other than anticonvulsant drugs. Though exhibiting rather weak anticholinergic properties, Navane should be used with caution in patients who are known or suspected to have glaucoma, or who might be exposed to extreme heat. or who are receiving atropine or related drugs. Use with caution in patients with cardiovascular disease. Also, careful observation should be made for pigmentary retinopathy, and lenticular pigmentation fine lenticular pigmentation has been noted in a small number of patients treated with Navane for prolonged.
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Table 1: adverse events at rate of ≥ 1% ; adult n 380 ; and pediatric n 291 ; clinical trial experience * reactions occurring in 3% - 10% of duragesic ® patients * reactions occurring in 10% or more of duragesic ® patients pediatrics the following adverse effects have been reported in less than 1% of the 510 adult post-operative and cancer patients studied: cardiovascular: bradycardia digestive: abdominal distention nervous: aphasia, hypertonia, vertigo, stupor, hypotonia, depersonalization, hostility respiratory: stertorous breathing, asthma, respiratory disorder skin and appendages, general: exfoliative dermatitis, pustules special senses: amblyopia urogenital: bladder pain, oliguria, urinary frequency post-marketing experience - adults the following adverse reactions have been reported in association with the use of duragesic ® and not reported in the pre-marketing adverse reactions section above: body as a whole: edema cardiovascular: tachycardia metabolic and nutritional : weight loss special senses: blurred vision urogenital: decreased libido, anorgasmia, ejaculatory difficulty drug abuse and addiction duragesic ® contains a high concentration of fentanyl, a potent schedule ii opioid agonist and pemoline.
Data from a phase II trial of atovaquone conducted in Zambia suggested that approximately 40% of the study population in this country were HIV-infected patients. The enrollment criteria were similar for the phase III trial of MALARONE conducted in Zambia and the results are presented in Table 7. Efficacy rates for MALARONE in this study population were high and comparable to other populations studied. The efficacy of MALARONE in the treatment of the erythrocytic phase of nonfalciparum malaria was assessed in a small number of patients. Of the 23 patients in Thailand infected with P. vivax and treated with atovaquone proguanil hydrochloride 1, 000 mg 400 mg daily for 3 days, parasitemia cleared in 21 91.3% ; at 7 days. Parasite relapse occurred commonly when P. vivax malaria was treated with MALARONE alone. Seven patients in Gabon with malaria due to P. ovale or P. malariae were treated with atovaquone proguanil hydrochloride 1, 000 mg 400 mg daily for 3 days. All 6 evaluable patients 3 with P. malariae, 2 with P. ovale, and 1 with mixed P. falciparum and P. ovale ; were cured at 28 days. Relapsing malarias including P. vivax and P. ovale require additional treatment to prevent relapse. The efficacy of MALARONE in treating acute uncomplicated P. falciparum malaria in children weighing 5 and 11 kg was examined in an open-label, randomized trial conducted in Gabon. Patients received either MALARONE 2 or 3 MALARONE Pediatric Tablets once daily depending upon body weight ; for 3 days n 100 ; or amodiaquine 10 mg kg day ; for 3 days n 100 ; . In this study, the MALARONE Tablets were crushed and mixed with condensed milk just prior to administration. In the per-protocol population, adequate clinical response was obtained in 95% 87 92 ; of the pediatric patients who received MALARONE and in 53% 41 78 ; of those who received amodiaquine. A response of RI resistance elimination of parasitemia but with recurrent parasitemia between 7 and 28 days after starting treatment ; was noted in 3% and 40% of the patients, respectively. Two cases of RIII resistance rising parasite count despite therapy ; were reported in the patients receiving MALARONE. There were 4 cases of RIII in the amodiaquine arm. Prevention of Malaria: MALARONE was evaluated for prophylaxis of malaria in 5 clinical trials in malaria-endemic areas and in 3 active-controlled trials in non-immune travelers to malaria-endemic areas. Three placebo-controlled studies of 10 to weeks' duration were conducted among residents of malaria-endemic areas in Kenya, Zambia, and Gabon. Of a total of 669 randomized patients including 264 pediatric patients 5 to 16 years of age ; , 103 were withdrawn for reasons other than falciparum malaria or drug-related adverse events. Fifty-five percent of these were lost to follow-up and 45% were withdrawn for protocol violations. ; The results are listed in Table 8.
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115 Rosen G, Marcove RC, Caparros B et al. Primary osteogenic sarcoma: the rationale for preoperative chemotherapy and delayed surgery. Cancer 1979; 43: 2163-2177. Rosen G, Murphy ML, Huvos AG et al. Chemotherapy, en bloc resection, and prosthetic bone replacement in the treatment of osteogenic sarcoma. Cancer 1976; 37: 1-11. Winkler K, Beron G, Delling G et al. Neoadjuvant chemotherapy of osteosarcoma: results of a randomized cooperative trial COSS-82 ; with salvage chemotherapy based on histological tumor response. J Clin Oncol 1988; 6: 329-337. Bacci G, Picci P, Ruggieri P et al. Primary chemotherapy and delayed surgery neoadjuvant chemotherapy ; for osteosarcoma of the extremities. The Istituto Rizzoli experience in 127 patients treated preoperatively with intravenous methotrexate high versus moderate doses ; and intraarterial cisplatin. Cancer 1990; 65: 2539-2553. Provisor AJ, Ettinger LJ, Nachman JB et al. Treatment of nonmetastatic osteosarcoma of the extremity with preoperative and postoperative chemotherapy: a report from the Children's Cancer Group. J Clin Oncol 1997; 15: 76-84. Goorin AM, Schwartzentruber DJ, Devidas M et al. Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: Pediatric Oncology Group Study POG-8651. J Clin Oncol 2003; 21: 1574-1580. Meyers PA, Heller G, Healey J et al. Chemotherapy for nonmetastatic osteogenic sarcoma: the Memorial Sloan-Kettering experience. J Clin Oncol 1992; 10: 5-15. Glasser DB, Lane JM, Huvos AG et al. Survival, prognosis, and therapeutic response in osteogenic sarcoma. The Memorial Hospital experience. Cancer 1992; 69: 698-708. Meyers PA, Gorlick R, Heller G et al. Intensification of preoperative chemotherapy for osteogenic sarcoma: results of the Memorial Sloan-Kettering T12 ; protocol. J Clin Oncol 1998; 16: 2452-2458. Grem JL, King SA, Wittes RE et al. The role of methotrexate in osteosarcoma. J Natl Cancer Inst 1988; 80: 626-655. Krailo M, Ertel I, Makley J et al. A randomized study comparing high-dose methotrexate with moderate-dose methotrexate as components of adjuvant chemotherapy in childhood nonmetastatic osteosarcoma: a report from the Childrens Cancer Study Group. Med Pediatr Oncol 1987; 15: 69-77. Bramwell VH, Burgers M, Sneath R et al. A comparison of two short intensive adjuvant chemotherapy regimens in operable osteosarcoma of limbs in children and young adults: the first study of the European Osteosarcoma Intergroup. J Clin Oncol 1992; 10: 1579-1591. Bacci G, Picci P, Ferrari S et al. Primary chemotherapy and delayed surgery for nonmetastatic osteosarcoma of the extremities: results of 164 patients preoperatively treated with high doses of methotrexate followed by cisplatin and doxorubicin. Cancer 1993; 72: 3227-3238. Souhami RL, Craft AW, Van der Eijken JW et al. Randomised trial of two regimens of chemotherapy in operable and penicillamine.
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9-11 February 2006 25th Advanced Nephrology: Nephrology for the Consultant San Diego, CA CONTACT: Website: nephrologysandiego 28 February 4 March 2006 13th International Congress on Metabolism and Nutrition in Renal Disease Merida, Yucatan, Mexico CONTACT: Website: isrnm-merida2006 1-4 March 2006 3rd NephroAsia 2006 Singapore, Singapore CONTACT: NephroAsia 2006 Congress Secretariat Tel.: 65-62-990-200 Fax: 65-62-517-555 Email: nephroasia nkfs 10-14 March 2006 Pediatric Nephrology Seminar XXXIII Miami Beach, FL CONTACT: Jos Strauss, M.D. Tel.: 305-667-3031 Fax: 305-667-3031 Email: strinter bellsouth and pennyroyal.
Delineate areas of positron emission in the presence of annihilation photon background. As the amount of back ground photon flux is increased, the resolution is degraded due to the broadening of the line response function. The reduction in resolution, however, is relatively minor con sidering the high levels of background simulated. The 1ev els of background used were much higher than would be expected in typical intraoperative applications in order to fully explore the capabilities of the detector. In humans, the median FDG concentration in breast tumors can be as.
LONG-TERM DEBT Long-term debt is any debt obligation that has a maturity date greater than one year. Examples of long-term debt are bonds, notes and loans with payback dates greater than one year. Pfizer's overall long-term debt is , 350.0 million, whereas Merck's overall long-term debt and notes payable is , 125.6 million overall. Pfizer uses the long-term debt with operating cash flow and short-term paper borrowings ; to provide funding for their operating activities, including Research & Development. To provide a more comprehensive understanding, Pfizer's portion of long-term debt compared to total liabilities is 12.22% a ; , whereas Merck's portion is 11.43% b ; . As is shown, Pfizer's long-term is less than 1% greater than Merck's. Pfizer's long-term debt is as follows and pentamidine
Gao B., Meier P.J.; Organic Anion Transport Across the Choroid Plexus. Microscopy Research and Technique 52 2001 ; 60-64 and pegasys.
No. 00.20 Page -2528. Transmittal of notice of receipt of funds in the total net amount of , 350 from the sale of county items at Houston Auto Auction on August 16. 29. Request for authorization for a list of county surplus and or confiscated property to be sold at auction, and for disposal of unsold surplus items. 30. Request for approval of property and equipment transfers within the county. 31. Request for approval of a renewal option with Houston Auto Auction, Inc., for auctioning services for the county for the period of January 1-December 31, 2001. Commissioners Court a. County Judge 1. Consideration of a resolution designating the week of October 1-7 as 4-H Day in the county. 2. Consideration of a resolution designating October 26 as Harris County Employees' Books Are Fun Book Fair Day in the county. 3. Request for approval for December 5 to be the date for the annual county Christmas Carol Sing. 4. Consideration of a resolution designating November 16 as Intercontinental Terminals Company Day in recognition of ITC being selected as 2000 Industry of the Year by the Deer Park Chamber of Commerce Salute to Industry Committee. 5. Request for approval for an employee to attend air quality discussions with the South Coast Regional Air Quality Board October 5-6 in Los Angeles at a cost not to exceed , 000. 6. Request for authorization for an employee of the Ryan White Planning Council Support Staff and a council volunteer to attend a meeting of the Texas Department of Health regarding Ryan White grant funds October 26-27 in San Antonio at an approximate total cost of , 000. 7. Recommendation by the Office of Emergency Management for authorization for two employees to attend the annual conference and exhibit of the International Association of Emergency Managers November 4-7 in Austin at an approximate total cost of , 400. b. Commissioner, Precinct 1 Request for approval of a revised list of election judges and alternate judges for a oneyear term and pentasa.
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