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Ord. No. 712-96. By Councilmen Patton and Rokakis by departmental request ; . An emergency ordinance authorizing and directing the purchase by contract of one electric scissor lift, for the Division of Water, Department of Public Utilities. Approved by Directors of Public Utilities, Finance, Law; Recommended by Committees on Public Utilities, Finance. The rules were suspended. Yeas 20 Nays 0. Read second time. Read third time in full. Passed. Yeas 20. Nays 0. Ord. No. 713-96. By Councilmen Patton and Rokakis by departmental request ; . An emergency ordinance authorizing and directing the purchase by requirement contract of office furniture, for the Division of Cleveland Public Power, Department of Public Utilities. Approved by Directors of Public Utilities, Finance, Law; Recommended by Committees on Public Utilities, Finance. The rules were suspended. Yeas 20 Nays 0. Read second time. Read third time in full. Passed. Yeas 20. Nays 0. Ord. No. 715-96. By Councilmen Paulenske, Johnson, Rybka and Rokakis by departmental request ; . An emergency ordinance authorizing the Director of Parks, Recreation and Properties to execute an easement granting to the Greater Cleveland Transit Authority certain easement rights in property located at South Marginal Road from west of East 9th Street to East 18th Street and declaring said easement rights no longer needed for public use. Approved by Directors of Parks, Recreation and Properties, City Planning Commission, Finance, Law; Relieved of Committees on Public Parks, Property and Recreation, City Planning; Recommended by Committee on Finance, when amended as follows: 1. In Section 1, at the end, strike "[Insert Legal]" and insert the following: "WATERFRONT TRANSIT LINE EASEMENT WEST OF EAST 9TH STREET CLEVELAND, OHIO Situated in the City of Cleveland, County of Cuyahoga, State of Ohio and more fully described as follows: Commencing at the intersection of the centerline of Erieside Avenue N.E. with the centerline of East 9th Street, 99.00 feet wide; Thence South 34 00' 00" East, along the said centerline of East 9th Street a distance of 540.24 feet to a point therein; Thence South 56 00' 00" West, a distance of 49.50 feet to a point in the Westerly right-of-way line of East 9th Street, also the Principal Place of Beginning for the parcel herein described; Thence South 34 00' 00" East, along the said Westerly right-ofway line a distance of 14.00 feet to a point therein; Thence along an arc of curve deflecting to the right, a distance of 132.26 feet to a point. Said curve having a radius of 261.50 feet, a delta angle of 28 58' 43", a tangent of 67.58 feet and a chord of 130.85 feet that bears South 69 11' 09" West.
Plete ; conditions. However, when exposure to MTSEA is carried out in the absence of chloride, its inhibitory effect is markedly blunted. This result suggests that the reaction of MTSEA with A483C is dependent on transporter conformation and, more specifically, that the conformations of the transporter present in the absence of extracellular chloride are insensitive to MTSEA. A more detailed discussion of the significance of this result is given later in the paper. Cysteine-scanning Mutagenesis of MSS 6 --In Fig. 8, we show the effects of 3 mM MTSEA and MTSET on NKCC1 mutants in which nine residues surrounding Ala-483 have been individually changed to cysteine. 86Rb uptake into HEK-293 cells transiently transfected with two of these mutants, P487C and A488C, is not significantly different from that seen with mock-transfected cells cf. Fig. 1 ; , indicating that these mutations do not result in a functional transporter at the plasma membrane. Fluxes via the remaining seven cysteine mutants are 50 100% of wild-type levels, but only I484C in addition to A483C is inhibited by MTSEA and MTSET. In Fig. 9, we examine the sensitivity of these mutants to inorganic mercury. Most of the mutants behave quite similarly to wild-type NKCC1 Fig. 9, solid line in all panels however, I484C middle panel, squares ; shows a dramatic stimulation of 86Rb uptake over the mercury concentration range of 110 M followed by inhibition at higher mercury concentrations. A similar but blunted effect appears to also occur for S480C upper panel, triangles ; and F486C lower panel, triangles.
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Yogurt drinks were consumed, the Ca absorption test was carried out and the diet was standardized. For the Ca absorption test, after a 12-h overnight fast, a yogurt drink enriched with 44Ca was consumed just at the start of a standard breakfast. The amount of carrier Ca present in the yogurt drink and standard breakfast was 250 mg. Within 0.5 h after ingestion of the oral dose of stable isotopes, the 48Ca solution was administered intravenously. The exact quantity of isotopes given by each route, as calculated by weighing the syringes in which the isotope solutions were taken up before and after isotope administration, ranged between 13.6 and 13.8 mg 44Ca and 0.97 and 0.99 mg 48 Ca. Before and after the bolus injection, blood pressure and heart rate were recorded for safety reasons. Preparation of stable isotope solutions. The stable isotopes were obtained from Chemgas Boulogne, France ; in the form of CaCO3. The abundances of the different Ca isotopes according to analysis by inductively coupled plasma mass spectrometry ICP-MS ; were as follows: 3.39% 40Ca, 0.06% Ca, 0.02% 48Ca for Ca enriched in 44Ca, and 2.82% 40Ca, 0.001% Ca for Ca enriched in 48Ca. The 44CaCO3 was converted into chloride salt, diluted with deionized water, followed by pH adjustment to 5. A similar procedure was followed for 48CaCO3, except that saline was used instead of deionized water. After filtration, the solution was distributed over 10-mL injection bottles and sterilized for 20 min at 121C. The 44CaCl2 was added to the yogurt drink in the morning of the test days 1 h before oral administration. Stable isotope analysis. The concentration of Ca in the urine samples was measured by atomic absorption spectrometry AAS ; . 44 Ca 43Ca and 48Ca 43Ca isotope ratios in urine were measured by ICP-MS VG PlasmaQuad, Fisons Instruments, UK ; after protein precipitation with 3.5% trichloroacetic acid, precipitation of Ca with saturated ammonium oxalate and dissolution of the formed calcium oxalate in 1.2 mol L HCl. The Ca concentration in the HCl solution was measured by AAS and diluted if necessary to adjust to 1 mg L Ca. Urine spot samples and 36-h urine samples taken during each treatment, before and after isotope administration to the same subject, were measured by ICP-MS within 1 d, together with a blank and a standard of 1 mg L Ca. All values were adjusted for minor deviations from standard Ca solutions with accepted natural ratios. All samples were measured in duplicate. Taking into account the amount administered and the natural abundance of these isotopes, true absorption was calculated from the isotope ratios in urine collected before dose administration and over the 36 h after dose administration, as reported by Van Dokkum et al. 1996 ; . Statistics. The data were analyzed by regression analysis for a Latin-square design SAS V6.12 V8.0, SAS Institute, Cary, NC
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Fig. 3. Model for negative modulation of antinociception by bivalent ligands. The inactive 1 ; and active 2 ; states of the - heterodimer are in equilibrium with each other. Univalent binding of the agonist pharmacophore of the bivalent ligand to the opioid receptor recognition site leads to state 3. Bridging with concomitant transformation of the receptor to the antagonist state negatively modulates the receptor 4 ; . Displacement of the antagonist pharmacophore of the bridged bivalent ligand by NTI disrupts tethering of the and receptors, thereby facilitating dissociation 5 ; . This model envisages the heterodimers to be either in an active or inactive state but not in a mixed state, except when the associated receptors are held together by the bridged bivalent ligand
The coordination and division of roles is a key issue of counter trafficking work. In the Balkan region, and clearly in the visited countries, there are coordination mechanisms established within the NPAs, unlike many other regions of the world. The division of roles is further decided by the mandate of the organisations. Clearly there are problems as regards the implementation of the NPAs, which largely relates to a general instability in the countries, their governance and political will. The co-ordination mechanisms have been described in chapter 3 and 4. Still, the division of roles and assumed roles of many of the actors is also discussed in the region. The role of IOM is within this context highly debated. As has been described above in chapter 4.3 on the establishment of coordination mechanisms and the relationship with different actors it is clear that there is a gap between what IOM define as their role and what other actors perceive as their role and responsibility. As described in chapter 4.3 IOM has, within the context of this program, generally good working relationship with governmental authorities, but an "outsider" relationship with the international actors and an unsatisfactory relationship and modes of work with NGOs. This does not comply with what is stressed in the IOM Constitution, 2, where the close collaboration with international organisations, governmental and non-governmental organisations is stressed. "Such cooperation shall be carried out in the mutual respect of the competence of the organisations concerned and restoril.
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Results Subject Characteristics. Seven male subjects were entered into and completed the study. The four EM subjects ranged from 38 to 54 years of age with a mean age of 45 years. The mean EM subject body mass index was 22.8 kg m2. The three subjects ranged from 19 to 49 years of age with a mean age of 35 years. The mean subject body mass index was 24.5 kg m2. Excretion of Atomoxetine and Its Metabolites. Urine and feces were collected until excreted radioactivity levels were less than 5 times that of environmental background. The recovery of radioactivity in urine and feces 168 h after the administration of 14C-atomoxetine for the EM subjects and at 264 h for the subjects was measured. The total recovery was similar in all subjects, independent of their CYP2D6 metabolic status. The combined recovery for EM and subjects was 97.2 1.1% with 89.0 3.5% excreted in urine and 8.2 3.2% in feces. The overall mean cumulative excretion of radioactivity in urine and feces is shown in Fig. 1 for EM and subjects. Although the elimination of radioactivity into the urine was the primary route of excretion regardless of CYP2D6 metabolic status, the amount of fecal excretion was different between EM and subjects. The cumulative percentage of radioactivity excreted in urine ranged from 89.7 to 99.9% in EM subjects and from 76.6 to 84.5% in subjects. The cumulative percentage of radioactivity excreted in feces ranged from 1.1 to 2.4% in EM subjects and from 13.1 to 21.6% in subjects. Within 24 h postdose, 89.4 3.7% of the total radioactive dose had been excreted by EM subjects, whereas only.
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The circuit court held an in camera hearing on the admissibility of evidence of Nurse Grim's prior morphine addiction and determined that the evidence was not relevant to whether Nurse Grim negligently combined two incompatible drugs on July 28, 1994. We agree. "`"Relevant evidence' means evidence having any tendency to make the existence of any fact that is of consequence to the determination of the action more probable or less probable than it would be without the evidence.' W.Va.R.Evid. 401." Syllabus Point 2, State v. Maynard, 183 W.Va. 1, 393 S.E.2d 221 1990 ; . The evidence in the instant case was undisputed that Nurse Grim gave the appellant a single injection of a combination of Solu-Medrol and Benadryl. The primary issue was whether Solu-Medrol and Benadryl are incompatible medications so that their combination in a single injection caused a negative reaction which resulted in injury to the appellant. Evidence concerning Nurse Grim's prior substance abuse does not have any tendency to make the incompatibility of Solu-Medrol and Benadryl more or less probable. Accordingly, we conclude that.
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TABLE 1.--Basic life-history parameters of Cavia magna in captivity and from a field population in Uruguay. For very small samples, single data points are given and rhinocort.
PrOFESSOr STEPHEn LIVESEy is CEO of the Australian Stem Cell Centre, returning to Australia in 00 to take up the post. He was co-founder and formerly Executive Vice-President and Chief Science Officer of LifeCell Corporation, new Jersey. A graduate of the university of melbourne, he was Associate Director of the Cryobiology research Center at the university of Texas, and a Wellcome Trust Senior research Fellow at St Vincent's Institute of medical research, melbourne, in 88. In , he became Vice-President of Scientific Development of LifeCell Corporation, and in Executive Vice-President and Chief Science Officer. Professor Livesey is the inventor of the company's tissue matrix and cell-preservation technology.
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Wings of their wimples as they gathered around the bearded man's bed vanished, and all was darkness once more. Roland waited for what might happen next, his skin cold. He tried to flex his hands and feet, and could not. He had been able to move his head perhaps fifteen degrees; otherwise he was as paralysed as a fly neatly wrapped up and hung in a spider's web. The low jingling of bells in the black . and then sucking sounds. As soon as he heard them, Roland knew he'd been waiting for them. Some part of him had known what the Little Sisters of Eluria were, all along. If Roland could have raised his hands, he would have put them to his ears to block those sounds out. As it was, he could only lie still, listening and waiting for them to stop. For a long time - for ever, it seemed - they did not. The women slurped and grunted like pigs snuffling half-liquefied feed out of a trough. There was even one resounding belch, followed by more whispered giggles these, ended when Sister Mary uttered a single curt word - 'Hais!' ; . And once there was a low, moaning cry - from the bearded man, Roland was quite sure. If so, it was his last on this side of the clearing. In time, the sound of their feeding began to taper off. As it did, the bugs began to sing again - first hesitantly, then with more confidence. The whispering and giggling recommenced. The candles were re-lit. Roland was by now lying with his head turned and restasis.
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Date of Birth and Incidence of Mental Deficiency. Hilda Knobloch, M.D., and Benjamin Pasamanick, M.D and rifabutin
11 from the wild type or the SDH4-17 enzymes. There is a slight reduction in the succinate-PMS reductase activity of the S71A enzyme. These data confirm that the primary defects in the F69V and S71A are not due to impaired assembly. In contrast, the H99L and the Y89OCH enzymes show significant reductions in their succinate-PMS reductase activities, indicating assembly defects. Quinone-reductase Activities of the SDH4 Mutants--We assayed mitochondrial membranes for malonate-sensitive succinate-dependent quinone reduction, using the soluble quinone analog, 2, 3-dimethoxy-5-methyl-6-decyl-1, 4-benzoquinone DB ; , and the reporter, 2, 6-dichlorophenol indophenol DCPIP ; Table II ; . The succinate-DB reductase activities of the F69V, the S71A.
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In summary, because of the sensitivity of the rabbit to intradermal infection by either rpv or vv-wrc followed by onset of lethal disease which includes recapitulation of most of the critical features of human smallpox general dissemination of virus, secondary lesions, respiratory involvement and lethal animal-to-animal transmission ; , the rabbit provides an excellent model for the efficacy testing of both antiviral drugs and vaccines and restoril.
The phenomenon of seizures aggravated by antiepileptic drugs is frequently overlooked by physicians. It should be considered a side effect of antiepileptics, especially in epileptic cases treated with multiple antiepileptics polytherapy ; and in cases of intractable epilepsy. In this report, we discuss this phenomenon after demonstrating its occurrence in four cases in different clinical settings. A child presented with status epilepticus as a complication of acute intoxication with carbamazepine. Another child who after starting treatment with carbamazepine developed myoclonic seizures, as a new type of seizure which disappeared after stopping carbamazepine; these myoclonic seizures represent a paradoxical reaction to carbamazepine. A third child who was treated for absence epilepsy with carbamazepine developed worsening of the seizures. This represents an inappropriate choice of antiepileptic drug for this type of seizure. A fourth epileptic child while on polytherapy with usual doses of sodium valproate and lamotrigine unexpectedly developed frequent prolonged absences and encephalopathy; he reverted to his base line state with dose reduction of both drugs. It is important to recognize this phenomenon, as it will help in reducing morbidity in epileptics by early and appropriate intervention and rifapentine.
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Effects of amitriptyline and mianserin on psychomotor skills and memory in man. British Journal of Clinical Pharmacology, 5, 53S 55S. Pharmacology , clinical features of depressed out-patients with response to amitriptyline and protriptyline. British Journal of Psychiatry, 114, 103 106. Psychiatry 114.
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