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Systemic Administration of CBD Blocks LPS-Induced Serum TNF. High levels of serum TNF in C57BL 6 mice were measured by bioassay 90 min after i.p. injection of LPS. Simultaneous injection of CBD, either i.p. or s.c., effectively abrogated the rise in serum TNF Table 5.
Tumor stroma generation and wound healing. N Engl J Med 1986, 315: 1650 Rnnov-Jessen L, Petersen OW, Bissell MJ: Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction. Physiol Rev 1996, 76: 69 Hewitt RE, Powe DG, Carter GI, Turner DR: Desmoplasia and its relevance to colorectal tumour invasion. Int J Cancer 1993, 53: 62 Lazard D, Sastre X, Frid MG, Glukhova MA, Thiery JP, Koteliansky VE: Expression of smooth muscle-specific proteins in myoepithelium and stromal myofibroblasts of normal and malignant human breast tissue. Proc Natl Acad Sci USA 1993, 90: 999 Ramadori G, Veit T, Schwogler S, Dienes HP, Knittel T, Rieder H, Meyer zum Buschenfelde KH: Expression of the gene of the alphasmooth muscle-actin isoform in rat liver and in rat fat-storing ITO ; cells. Virchows Arch B Cell Pathol Incl Mol Pathol 1990, 59: 349 Shimizu S, Yamada N, Sawada T, Ikeda K, Kawada N, Seki S, Kaneda K, Hirakawa K: In vivo and in vitro interactions between human colon carcinoma cells and hepatic stellate cells. Jpn J Cancer Res 2000, 91: 12851295 Micke P, Ostman A: Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy? Lung Cancer 2004, 45 Suppl 2 ; : S163S175 Tuxhorn JA, Ayala GE, Rowley DR: Reactive stroma in prostate cancer progression. J Urol 2001, 166: 24722483 Lieubeau B, Garrigue L, Barbieux I, Meflah K, Gregoire M: The role of transforming growth factor beta 1 in the fibroblastic reaction associated with rat colorectal tumor development. Cancer Res 1994, 54: 6526 Sieweke MH, Bissell MJ: The tumor-promoting effect of wounding: a possible role for TGF-beta-induced stromal alterations. Crit Rev Oncog 1994, 5: 297311 Benjamin LE, Hemo I, Keshet E: A plasticity window for blood vessel remodeling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF. Development 1998, 125: 15911598 Gerhardt H, Betsholtz C: Endothelial-pericyte interactions in angiogenesis. Cell Tissue Res 2003, 314: 1523 Uemura A, Ogawa M, Hirashima M, Fujiwara T, Koyama S, Takagi H and eloxatin.
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Serotonin 5-HT ; plays an important role in various behavioral and physiological functions Fozzard, 1989; Jacobs and Azmitia, 1992 ; . The uptake of synaptic 5-HT through Na Cl dependent serotonin transporter SERT ; is the principal process of terminating serotonergic neurotransmission Barker and Blakely, 1995; Povlock and Amara, 1997 ; . Altered SERT expression and two polymorphic regions in SERT promoter have been implicated in various types of psychopathology Montgomery, 1995; Blakely et al., 1997; Murphy et al., 2001 ; . SERT is one of the primary targets for tricyclic antidepressants, serotonin-selective reuptake inhibitors, and drugs of abuse Rudnick and Wall, 1992; Barker and Blakely, 1995 and emend.
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