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Irvine RRA et al: The CAG and GGC microsatellites of the androgen receptor gene are in linkage disequilibrium in men with prostate cancer. Cancer Res 1995; 55: 1937-1940. Isaacs JT: Hormonal balance and the risk of prostatic cancer. Journal of Cellular Biochemistry 16H suppl ; : 107-108, 1992. Iversen P, Tyrrell CJ, Kaisary AV, Anderson JB, Baert L, Tammela T et al. Casodex Bicalutamide ; 150-mg monotherapy compared with castration in patients with previously untreated nonmetastatic prostate cancer. Urology 51: 389-96, 1998. Jaffe JM, Malkowicz SB, Walker AH, MacBride S, Peschel R, Tomaszewski J, et al. Association of SRD5A2 genotype and pathological characteristics of prostate tumors. Cancer Res 2000; 60 6 ; : 1626-30. Jenkins EP, Andersson S, Imperato-McGinley J, Wilson JD, Russell DW. Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductase. J Clin Invest 1992; 89 1 ; : 293-300. Jenkins PJ, Grossman A. The control of the gonadotrophin releasing hormone pulse generator in relation to opioid and nutritional cues. Hum Reprod 1993; 8 Suppl 2 ; : 154-161. Johansson J-E, Andersson S-O, Beckman K-V, Lingrdh G, Zador G. Clinical evaluation of Flutamide and Estramustine as initial treatment for metastatic carcinoma of prostate. Urol 27: 55-9, 1987. Johansson J-E, Andersson S-O, Holmberg L et al. Primary orchiectomy versus estrogen therapy in advanced prostatic cancer - a randomized study: results after 7 to 10 years of followup. J Urol 145: 519-23, 1991. Kaisary AV, Tyrell CJ, Peeling WB et al. Comparison of LHRH analogue Zolodex ; with orchiectomy in patients with metastatic prostatic carcinoma. Br J Urol 67: 502-8, 1991. Kantoff PW, Febbo PG, Giovannucci E, Krithivas K, Dahl DM, Chang G, et al. A polymorphism of the 5 alpha-reductase gene and its association with prostate cancer: a case-control analysis. Cancer Epidemiol Biomarkers Prev 1997; 6 3 ; : 189-92. Kantoff PW, Halabi S, Conaway M, Picus J, Kirshner J, Hars V, Trump D, Winer EP, Vogelzang NJ. Hydrocortisone with or without mitoxantrone in men with hormone-refractory prostate cancer: results of the cancer and leukemia group B 9182 study. J Clin Oncol 1999; 17: 2506. Kavarnos GJ. Fundamentals of Photoinduced Electron Transfer. 1 ed. Aug. 19, 1993 John Wiley & Sons; ISBN: 0471187305 Kennealey GT, Furr BJA. Use of the nonsteroidal anti-androgen casodex in advanced prostatic carcinoma. Urol clin North 18: 99-110, 1991.
Before reconstitution Store at controlled room temperature, 20 to 25C 68 to 77F ; After reconstitution with 0.9% Sodium Chloride Injection, USP Do NOT refrigerate as crystallization may occur Stable for 24 hours if stored at controlled room temperature 20 to 25C 68 to 77F ; Discard unused portion. Estramustine should be swallowed with water. TABLE 3. Effect of rsmG mutation on the emergence of high level Sm-resistant mutantsa. It is well known that the unfolding reactions of different proteins display certain common properties 57, 58 ; . The positive molar heat capacity change associated with the unfolding of a protein, for example, is commonly attributed to the hydrophobic interaction, although other factors may contribute to U C 41, 57 ; . A large positive molar heat capacity change of the unfolding of MM-CK induced by acid, 8.78 kcal mol-1 K-1, at all temperatures examined indicates that hydrophobic interaction is the dominant driving force stabilizing the native structure of this protein. U C P , the thermodynamic term which has been most often scaled to structural feature of a protein 58 ; . The value of U C per amino acid residue for MM-CK, 11.6 0.9 cal K-1 mol res ; -1, is the same order of magnitude as those for monomeric proteins 13.9 0.5 cal K-1 mol res ; -1 58 and homodimeric pea lectin 11.4 cal K-1 mol res ; -1 59 , suggesting that U C P , approximately proportional to the size of a protein. Combining the results from ESI-TOF MS, ITC, fluorescence spectroscopy and glutaraldehyde crosslinking SDS-PAGE we conclude that the acid-induced.

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6. Kreis W. Budman DR, Fetten J et al. Phase I trial of the combination of daily estramustine phosphate and intermittent docetaxel in patients with metastatic hormone-refractory prostate cancer. Ann Oncol 1999, 10- 33-8. Petryiak DP. Macarthur RB, O'Connor J et al. Phase I trial of docetaxel with estramustine in androgen-independent prostate cancer. J Clin Oncol 1999: 17: 958-67. Sinabaldi VJW. Carducci M. Laufer M, Eisenberger M. Preliminary evaluation of a short course of estramustine phosphate and and eszopiclone.

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1. Brady R, Gal AE, Bradley RM, Martensson E, Warshaw AL, Laster L 1967 ; N Engl J Med 276: 11631167. 2. Desnick R, Ioannou YA, Eng CM 2001 ; in The Metabolic and Molecular Bases of Inherited Disease, ed Charles R, Scriver, Arthur L, Beaudet WS, Sly DV McGrawHill, New York ; , 8th Ed, pp 37333774. 3. Mitsias P, Levine SR 1996 ; Ann Neurol 40: 817. 4. Moore D, Ye F, Schiffmann R, Butman JA 2003 ; AJNR 24: 10961101. 5. Moore D, Altarescu G, Ling GSF, Jeffries N, Frei K, Weibel T, Charria-Ortiz G, Ferri R, Brady RO, Schiffmann R 2002 ; Stroke 33: 525531. 6. Moore DF, Scott LJC, Gladwin MT, Altarescu G, Kaneski C, Suzuki K, Pease-Fye M, Ferri R, Brady RO, Herscovitch P, Schiffmann R 2001 ; Circulation 104: 15061512. 7. Moore DF, Ye F, Brennan ML, Gupta S, Barshop BA, Steiner RD, Rhead WJ, Brady RO, Hazen SL, Schiffmann R 2004 ; J Magn Reson Imaging 20: 674683. 8. Moore DF, Pursley R, Altarescu G, Schiffmann R, Dimitriadis E 2001 ; in 14th IEEE Conference on Computer-Based Medical Systems, eds Thomas G, Long R IEEE, Bethesda, MD ; , pp 216221. 9. Schiffmann R, Kopp J, Austin H, Sabnis, Sharda, Moore DF, Weibel T, Balow J, Brady RO 2001 ; J Med Assoc 285: 27432749. 10. Bodary PF, Shen Y, Vargas FB, Bi X, Ostenso KA, Gu S, Shayman JA, Eitzman DT 2005 ; Circulation 111: 629632. 11. Ohshima T, Schiffmann R, Murray GJ, Kopp J, Quirk JM, Stahl S, Chan CC, Zerfas P, Tao-Cheng JH, Ward JM, Brady RO, Kulkarni AB 1999 ; Proc Natl Acad Sci USA 96: 64236427. 12. Shen Y, Bodary PF, Vargas FB, Homeister JW, Gordon D, Osteno KA, Shayman JA, Eitzman DT 2006 ; Stroke 37: 11061108. 13. Eitzman D, Bodary PF, Shen KY, Khairallah CG, Wild SR, Abe A, ShafferHartman J, Shayman JA 2003 ; J Soc Nephrol 14: 298302. 14. Roepman R, Bernoud-Hubac N, Schick DE, Maugeri A, Berger W, Ropers HH, Cremers FP, Ferreira PA 2000 ; Hum Mol Genet 9: 20952105. 15. Castagnet P, Mavlyutov T, Cai Y, Zhong F, Ferreira P 2003 ; Hum Mol Genet 12: 18471863. 16. Ferreira PA 2005 ; Hum Mol Genet 14: R259R267. 17. Lu X, Guruju M, Oswald J, Ferreira PA 2005 ; Hum Mol Genet 14: 13271340. 18. Browne MW 1984 ; Br J Math Stat Psychol 37: 6283. 19. Faraci F, Didion SP 2004 ; Arterioscler Throm Vasc Biol 24: 13671373. 20. Schafer J, Stimmer K, 2004 ; Bioinformatics 1: 114. 21. Halpern J, Pearl J 2001 ; in Proceedings of 17th Conference on Unceratinty in Artificial Intelligence Morgan Kauffmann, San Francisco, CA ; , pp 194202.

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