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Morris C, Iacobelli S, Brand R, Bjorkstrand B, Drake M, Niederwieser D, Gahrton G. Benefit and Timing of Second Transplantations in Multiple Myeloma: Clinical Findings and Methodological Limitations in a European Group for Blood and Marrow Transplantation Registry Study, 1674 Morris DE, see Fried DB see Socinski MA Morris J, see Ajani JA Morris M, see Eifel PJ see Scher HI Morris M, Blessing JA, Monk BJ, McGehee R, Moore DH. Phase II Study of Cisplatin and Vinorelbine in Squamous Cell Carcinoma of the Cervix: A Gynecologic Oncology Group Study, 3340 Morrow M, see Golub RM Morschhauser F, see Mounier N Morselli M, see Potenza L Mortimer JE, see Tripathy D Morton DL, see Lee JH see Takeuchi H Morton RF, see Goldberg RM Moschos SJ, Kirkwood JM, Konstantinopoulos PA. Present Status and Future Prospects for Adjuvant Therapy of Melanoma: Time to Build upon the Foundation of High-Dose Interferon Alfa-2b editorial ; , 11 Moschovi M, see French CA Moscinski L, see Johnson JL Moses MA, see Chan LW Mosley ST, see Rich TA Mossavar-Rahmani Y, see Chlebowski RT Motzer RJ, see Kondagunta GV Motzer RJ, Bacik J, Schwartz LH, Reuter V, Russo P, Marion S, Mazumdar M. Prognostic Factors for Survival in Previously Treated Patients With Metastatic Renal Cell Carcinoma, 454 Motzer RJ. In Reply correspondence ; , 1158 Moul JW, see Amling CL see Scher HI Moullet I, see Hequet O Mounier N, Gisselbrecht C, Briere J, Haioun C, Feugier P, Offner F, Recher ` C, Stamatoullas A, Morschhauser F, Macro M, Thieblemont C, Sonet A, Fabiani B, Reyes F. Prognostic Factors in Patients With Aggressive Non-Hodgkin's Lymphoma Treated by Front-Line Autotransplantation After Complete Remission: A Cohort Study by the Groupe d'Etude des Lymphomes de I'Adulte, 2826 Mountain A, see Palmer DH Mouridsen H, Chaudri-Ross HA. In Reply correspondence ; , 3200 Mouridsen HT, see Ejlertsen B Mouridsen HT. Exemestane Following Tamoxifen in Postmenopausal Women With Primary Breast Cancer correspondence ; , 3833 Mourits MJE, see Buijs C Moyano J, see Bruera E Mrozek K, see Byrd JC see Marcucci G Muanza T, see Chan LW Muckaden MA, see Laskar S Mueller SP, see Antoch G Muennig P, see Mandelblatt JS Muggia FM, see Hochster H Muhr-Wilkenshoff F, see Kiewe P Mulders PFA, see Patard J-J Muler JH, McGinn CJ, Normolle D, Lawrence T, Brown D, Hejna G, Zalupski MM. Phase I Trial Using a Time-to-Event Continual Reassessment Strategy for Dose Escalation of Cisplatin Combined With Gemcitabine and Radiation Therapy in Pancreatic Cancer, 238 Mulhern RK, see Fouladi M see Merchant TE.
Medico-Legal Update invites articles, case reports, newspaper clippings, report of medico-legal activities to update the knowledge of readers in scientific disciplines such as Forensic Medicine, Forensic Sciences, Environmental Hazards, Toxicology, etc. The following guidelines should be noted: 1. Please send two hard copies complete in all respect along with one copy in floppy disk CDROM. The article can also be sent through e-mail as attachment. 2. The article should be accompanied by a declaration from all authors that it is an original work and has not been sent to any other journal for publication. 3. References should be in Vancouver style. 4. As a policy matter, journal encourages articles regarding new concepts and new information.
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Cost is 0 per person. Prepayment or invoice is required; checks will not be accepted at the door. Lunch is not included. Requests received that do not include your facility's Medicare provider number cannot be processed. Confirmation cards for this seminar will be sent to the attention of the participant at your facility's main billing address. Please contact the person receiving your facility's Medicare mail to obtain your confirmation card. Registration closes five days prior to session or when seating is filled. Please photocopy this registration form as needed for additional participants.
European Journal of Echocardiography -- The Aim of the journal is to publish high-quality, peer-reviewed articles on the ultrasonic examination of the cardiovascular system. The journal will publish original research articles, Guest Editorials, Reviews, Technical Evaluations, Case Reports and Letters to the Editor. Every year, the abstracts from Euroecho will be published as a supplement. In the first instance, the journal will be published quarterly.
Protect the wildlife of the Islands and the sea and conserve or restore the landscape for the benefit and enjoyment of the public. This is both a wonderful challenge and a heavy responsibility for a small charity. We have achieved a great deal through a dedicated group of staff and volunteers, and have established a solid base of local and visitor members, but have now reached a stage where we urgently need more funding to stand a chance of delivering the sort of stewardship these magical islands deserve. Only 2, 000 people live in Scilly the local population can't provide all the funds we need to support the work we are doing. If we are not able to carry on, and do more, Scilly will soon look and feel very different, and much of what makes the Islands so rich and special will be lost forever. In a short space of time, footpaths would disappear and bracken and gorse would take over the landscape, destroying smaller plants and obliterating archaeological remains. Without active management and protection, habitats would be destroyed and the rarer birds and insects would be under threat of decline or extinction. If you have been touched by the magic of Scilly, please support the Save Wild Scilly Appeal with a gift of as much as you can afford. Whatever amount you give will be put to good use immediately and will help deliver the practical conservation work that is so badly needed. The Isles of Scilly Wildlife Trust would like to thank the Duchy of Cornwall and the Tresco Estate for their support with this appeal
In Mexico, the lack of soil knowledge is one of the main limitations to yield and maintain sustainable agricultural banana production systems. Because of this, a regional study was started to characterize and establish the main references soils for banana production in the Pacific Central Region of Mexico; in this work, the one for the Coahuayana, Michoacan area is presented. Findings showed that numerous soils are used for banana 12 soil units of FAO system ; , and the main processes of soil formation are the transport of calcium carbonate, clays and salts. A soil chronosequence was found in the landscape; besides a preliminary diagnostic of physical and chemical soil problems was done in the field; this might help to prevent and correct pH, salt accumulation and mechanical impedance to plant root penetration into the soil and exenatide.
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2 h, the cells were stained with either anti-CD4 and KJ1-26 mAb, or with anti-CD8 and Ly-5.1 mAb, fixed in 2% formaldehyde, and permeabilized in PBS containing 2% FCS, 0.5% saponin, 2% rat serum, and 0.2% sodium azide. The cells were then stained with anti-IL-2 and anti-IFN- mAb in permeabilization buffer. One thousand CD4 , KJ1-26 , or CD8 , Ly 5.1 events were generally collected. LACK-specific T cells were identified in 16.2 mice by staining with I-Ad LACK fluorescent multimers 21 ; . I-Ad LACK multimers were obtained by incubating I-Ad LACK dimers 3 g sample ; with Alexa 488coupled protein A Molecular Probes; 0.3 g sample ; in PBS for 30 min at room temperature. Free protein A binding sites were saturated by the addition of total IgG 1 g sample ; . A total of 6 105 LN cells was first incubated with a blocking buffer 5% rat serum and 95% culture supernatant of 2.4G2 anti-FcR mAb-producing hybridoma cells ; for 20 min to saturate the Fc receptors and then stained with I-Ad LACK multimers for 1 h on ice in PBS supplemented with 0.5% BSA. Thereafter, the cells were stained with PE- or PerCP-labeled anti-CD4 and anti-CD44 mAb and with allophycocyanin-labeled anti-CD8a, anti-CD11b, anti-B220 mAb BD Pharmingen ; . TOPRO-3 1 nM final; Molecular Probes ; was added to the sample just before flow cytometry analysis to discriminate viable and dead cells. CD8a , CD11b , B220 , TOPRO cells were excluded by electronic gating during the acquisition. A total of 50 100 103 CD4 T cells was acquired using a FACSCalibur flow cytometer BD Biosciences ; . To determine the frequency of LACK-specific cytokine-producing cells, 1 106 LN cells were cultured with unpulsed or LACK peptide-pulsed splenocytes derived from D011.10 TCR Tg mice for 4 h. During the last 2 h, brefeldin A 10 g ml; Sigma-Aldrich ; was added to the cultures. Cells were then stained with anti-CD4 mAb and anti-KJ1-26 mAb to exclude splenic DO11.10 CD4 T cells ; , fixed, permeabilized, and further stained with anti-IL-2 and anti-IFN- mAb. Cytokine release was determined in CD4 , KJ1-26 cells by flow cytometry. The significance of differences between the experimental groups was tested by statistical analysis with an unpaired two-tailed Student's t test.
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6 Crone L. dark K, Albritton W, Cronk S, Rea L, Tan L. Relation between oral Herpes simplex and the use of epidural morphine in obstetric patients. Society for Obstetric Anesthesia and Perinatology. Scientific abstract. Salt Lake City, May 1986, 124. 7 Douglas MJ, Thomas EE, McMorland GH, Anderson J, Cairns G. Epidemiology of HSV-I infection in the puerperal population - does epidural morphine cause recrudescence? Society for Obstetric Anesthesia and Perinatology. Scientfic abstract. Salt Lake City, May 1985, 125. 8 Cardan E. Herpes simplex after spinal morphine. Anaesthesia 1984; 39: 1031. BelsheRB Ed ; . Textbook of Human Virology. Massachusetts: PSG Publishing Co Inc, 1984: 814-27. 10 Whitley RJ, Nahmias AJ, VisintineAM, Fleming CL, Alford CA. The natural history of Herpes simplex virus infection of mother and newborn. Pediatrics 1980; 66: 489-94. Prober CG, Sullender WM, Yasukawa LL, Au DS, Yeager AS, Arvin AM. Low risk of Herpes simplex virus infections in neonates exposed to the virus at the time of vaginal delivery to mothers with recurrent genital herpes infections. N Engl J Med 1987; 316; 240-4. Joyce TH, Marx GF. Regional anesthesia and herpes. Society for Obstetric Anesthesia and Perinatology Newsletter 1984; 14: 1. Ramanathan S, ShethR, TurndorfH. Anesthesia for caesarean section in patients with genital herpes infections: a retrospective study. Anesthesiology 1986; 64: 807-9. Ravindran RS, Gupta CD, Stoops CA. Epidural analgesia in the presence of Herpes simplex virus type 2 ; infection. Anesth Analg 1982; 61: 714-5!
70000 Nonvascular. Non vascular cover bryophytes, non-crustose lichens, and algae ; dominant, generally forming at least 25% cover. Nonvascular cover may be less than 25% where it exceeds tree, shrub, dwarf-shrub, and herb cover, respectively. Crustose lichen dominated areas should be placed in the Sparse Vegetation class 80000 and ezetimibe.
Clr ina bhfiosraonn trir fear g as Conamara a n-oidhreacht fharraige le turas seoltireachta ar a chuanta, a chrompin agus a oilein. Beidh s dian ar Dhonncha Mac Con Iomaire, a r Chilln agus ar Stiof n Mac Donncha iomln na staire a thabhairt leo sa turas seo ach nl ann ach ts mar go gcrochfaidh siad na seolta ars do chlracha breise ar TG4 sa bhFmhar seo chugainn. 29 Nollaig. 8pm.
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Reference: coombes rc, paridaens r, jassem j et al first mature analysis of the intergroup exemestane study: a randomized trial in disease-free, postmenopausal patients with early breast cancer randomized to continue tamoxifen to to switch to exemestane following an initial 2-3 years of adjuvant tamoxifen.
Breast cancer is the most common cause of cancer death in women in Ireland. More than 25, 000 women in Ireland are living with a diagnosis of breast cancer and it is projected that an estimated 2, 171 new cases will be diagnosed and 650 women will die from their disease during 2006. Breast cancer is, in reality, a heterogeneous group of tumours, defined by various biological hallmarks. Substantial advances in the treatment of both early and advanced stage breast cancer have been made in the past number of years, none more so than in the area of biological therapies. HORMONAL THERAPIES About 60% of breast tumours express the oestrogen receptor ER + ; . patients with hormone-receptorpositive breast cancer, five years of tamoxifen reduces the risk of breast cancer recurrence by 47% and the risk of death by 26%. Tamoxifen also reduces the incidence of contralateral and second primary breast cancer. Tamoxifen is relatively well tolerated; however, it is not perfect, as about half the treated women relapse over time. Embolic events and endometrial carcinoma are among the most serious adverse effects and, although rare, should not be overlooked. These risks are lower in pre-menopausal women where the benefits outweigh the risks of treatment overall. Tamoxifen may also play a role in breast cancer prevention. Two trials have found that contralateral breast cancer incidence in women treated with adjuvant tamoxifen was reduced by up to 49%. AROMATASE INHIBITORS Tamoxifen has, to date, been the most successful targeted therapy in the treatment of breast cancer. It inhibits the action of oestrogen by competitively binding to the oestrogen receptor. By comparison, aromatase inhibitors block the conversion of androstenedione to oestrone and oestradiol in the plasma and peripheral tissues. There are currently three aromatase inhibitors licensed for use in Dr Maeve Waldron Ireland: the non-steroidal aromatase inhibitors Lynch anastrozole Arimidex ; and letrozole Femara ; and the steroidal exemestane Aromasin ; . Professor Des Aromatase inhibitors are used solely in postCarney menopausal women in whom circulating oestrogen is primarily derived from the conversion of Mater Misericordiae androstenedione produced by the adrenals ; to University Hospital, oestrone and oestradiol in the peripheral tissues. In Dublin pre-menopausal women, most of the circulating oestrogen is produced by the ovaries and aromatase inhibitors produce a relative increase in circulating oestrogen through a hypothalamic-pituitary feedback mechanism, counteracting the desired effect. Several studies have evaluated aromatase inhibitors in the treatment of post-menopausal women with early stage breast cancer. These studies have assessed aromatase inhibitors either as initial therapy, as extended therapy after four to six years of tamoxifen or as crossover therapy after two to three years of tamoxifen. Notably, none of these trials have yet shown a statistically significant improvement on survival in comparison to tamoxifen alone. The results of the Arimidex, Tamoxifen, Alone or in Combination Trial ATAC ; suggest that five years of anastrozole is superior to tamoxifen or the combination of tamoxifen and anastrozole in hormone-receptor-positive post-menopausal breast cancer patients. Disease-free survival, although not overall survival, was prolonged. The International Breast Cancer Study Group BIG-1.98 compared tamoxifen alone for five years, letrozole alone for five years, tamoxifen for two years followed by letrozole for three years, or letrozole for two years followed by tamoxifen. Disease-free survival was better in the letrozole treated patients, but again an overall survival benefit has not been proven. Several trials have studied the use of tamoxifen for two to three years followed by an aromatase inhibitor. The IES trial showed a significant and faslodex.
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Both the top and bottom of the stairs. For steps with short treads or a high rise, keep any coverings thin and tightly affixed to maximize the useable tread space. Avoid soft treads with a large rounding at the edge. For winding or curved stairs, be sure to provide a handrail on both sides especially where the stairway includes combinations of rectangular or tapered treads. Use a slip resistant, rough finish on stairs that are prone to getting wet. Make sure to fasten all coverings on stairs securely. Don't place any objects or loose rugs on steps and landings. Position handrails at about elbow height, and extend them on both sides for the full length of the stairway. Lastly, always be cautious, deliberate and not rushed when taking the stairs. Hold on to the handrails, wear shoes or slippers that fit properly and have a non-slip sole, remove reading glasses, switch on stair lights and most importantly always take your time, especially when using an unfamiliar stairway. For more information or a free copy the "About Your House' fact sheet Preventing Falls on Stairs or other facts on owning, maintaining and renovating your home call CMHC at 1-800-668-2642 or visit the web site at cmhc.
Suppression of Ovarian Function SOFT ; in Premenopausal Breast Cancer Patients Eligibility: Premenopausal endocrine responsive, ER and or PR, mastectomy or lumpectomy, prior adjuvant neoadjuvant chemo ok, patients not receiving chemo must be randomized within 12 wks post-op, prior Herceptin allowed, node positive or negative. Treatment: Tamoxifen x 5 yrs. vs. Tamoxifen or Exemestane x 5 yrs. + Ovarian function suppression with one of the following: Triptorelin x 28 days or surgical oophorectomy or ovarian irradiation x 4 or days. Arm 3: Exemestane x 5 yrs. + EXEMESTANE AND TRIPTORELIN SUPPLIED and felbamate.
Martine J Piccart-Gebhart is Associate Professor in Oncology at the Free University of Brussels and Head of the Chemotherapy Department at the Jules Bordet Institute. Dr Piccart-Gebhart is a member of numerous professional organisations, including the American Society of Clinical Oncology ASCO ; , the American Association for Cancer Research AACR ; , and the European Society of Medical Oncology ESMO ; . She also plays an active role in new drug development and has been particularly involved in the development of docetaxel, capecitabine, trastuzumab, letrozole, exemestane and pegfilgrastim, both as a researcher and as a clinical expert for registration. Dr PiccartGebhart is Founder and Chair of the Breast International Group BIG ; , and has contributed to more than 30 books on cancer, as well as being on the editorial board of several journals. An invited speaker at more than 150 international symposia, Dr Piccart-Gebhart teaches at the Universit Libre de Bruxelles and the European Society of Medical Oncology ESMO ; . She received her doctor of philosophy degree at the Free University of Brussels in 1993, her European certification in medical oncology was obtained in London in 1989 and she earned her oncology qualifications at the New York University NYU ; Medical Center in New York, where she trained between 1983 and 1985 as a clinical research associate. Dr Piccart-Gebhart received her certification in internal medicine 1983 ; and her degree in medicine 1978, summa cum laude, Prix Fleury Mercier ; in Belgium and exemestane.
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