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The MIC is desirable. This is determined by the characteristics of absorption, distribution, metabolism and excretion of the drug. The excretion of a drug will be compromised by renal or hepatic disease, certain drugs being mainly excreted by the kidneys and others metabolised by the liver. The tetracyclines, streptomycin and sulphonamides, should be avoided in renal disease. The dose and its route of administration, oral, parenteral, sub-lingual, rectal, intranasal or subcutaneous, are also important. In severe infections such as meningitis, osteomyelitis and endocarditis, where effective concentrations of antibiotics are required at the appropriate site rapidly, the intravenous route is indicated, recently even in the out-patient situation19. Tobradex and tobrex are registered trademarks of alcon inc tobi is a registered trademark of chiron corporation.

FIG . 12. A and B: divergence plus far accommodation 0V 0 A ; far-response cell cell 49 in Table 1 ; . A: scatterplot and linear regression of firing rate as a function of vergence angle for normal viewing ; and conflict viewing ; . B: scatterplot and linear regression of firing rate as a function of accommodation for normal viewing ; and conflict viewing condition ; . C and D: divergence minus far accommodation 0V A ; IP far-response cell cell 63 in Table 1 ; . C: scatterplot and linear regression of firing rate as a function of vergence angle for normal viewing ; and conflict viewing ; . D: scatterplot and linear regression of firing rate as a function of accommodation for normal viewing ; and conflict viewing condition ; . Scale bar 4 MA and 4 diopters!

Few simple words e.g., even once at Q32 ; could have an important impact on accuracy without affecting burden in any significant way. 3 ; On a similar topic, several questions combined concepts that might appear loosely associated with one another e.g., acupuncture and body piercing; needle-sticks and coming into contact with someone else's blood ; . This might seem like a justifiable decision to reduce the number of questions, but sometimes it leads to confusion, or respondents' attention might focus too heavily on one of the two components. Generally, we recommend splitting these into separate questions. 4 ; False positive errors appeared to be more common than false negative errors. Obviously, false positives are preferable and can often be cleared up in follow-up discussions with blood center staffs. False negatives are potentially more serious. The results below provide details about the false negatives we encountered. Some of these point to the need for a question revision. Unfortunately, some others are attributable to the frailty of human memory rather than a question flaw per se. Intensive probing sometimes brought memories to the surface that had not been included in initial responses e.g., a sexual partner from African, and a shot that had been received that morning ; . In lieu of making the instrument considerably longer and more complex, the most effective strategy here is probably to remind donors at various points of the need for careful thought and accurate information. 5 ; Clearly, respondents will not have complete knowledge about some of the topics addressed in the questionnaire. People may not know for certain whether they have been exposed to the saliva of a person with hepatitis, or whether one of their sexual partners had used needles for drugs. Many responses were qualified by expressions such as "as far as I know"; obviously, the accuracy of their judgment cannot be guaranteed. Responses seemed to be tempered by assessments of risk e.g., I don't know anyone who has hepatitis, so chances are I was not exposed to it ; . Participants who thought they had some risk of exposure but no definite evidence ; tended to have the hardest time answering. "Yes" responses generally indicated certainty that they had been exposed. 6 ; Several concepts were open to multiple interpretations, most notably "had sex." We think that respondents will tend to interpret the questions pragmatically rather than literally meaning that if they thought any form of intimate sexual contact had exposed them to the risk in question, then they would answer affirmatively even if they did not literally think of such behavior as "having sex." ; Nevertheless, there is no guarantee of consistency, and we support the Task Force's recent decision to substitute "had sexual contact" defined in the educational materials ; for "had sex" in all questions. 7 ; The cognitive testing focused on the quality of question wording, but it also became obvious that formatting of the instrument could create some errors. For example, some participants lost track of reference periods e.g., "in the past 12 months" ; . This was almost certainly due to the layout of our questionnaire on the page. The final instrument should be designed with such considerations in mind and tobi.

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