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Groups. These findings are difficult to interpret. There are 2 possible explanations: 1 ; It might be that participants in the treatment groups truly felt more subjective benefit than those in the placebo group and, therefore, assumed more often that they had received the treatment and the opposite in the placebo group ; . This would mean that the treatment was more effective than placebo on a subjective level. 2 ; Some participants might have found out whether the treatment they received was echinacea or placebo. Because of the characteristic taste of echinacea extracts it is almost impossible to prepare a completely indistinguishable placebo. Unblinding is rarely discussed in clinical research.14, 15 There are no reliable procedures to quantify the degree of this problem in a trial. The mutual interactions between perceived efficacy, adverse effects, and guesses make an analysis difficult. In our trial the guesses of the participants were correct in about half of the cases 53.
There are nine different species of echinacea but the one most commonly used and referred to is the echinacea purpurea.
Romidepsin is a histone deacetylase inhibitor HDACi ; . HDACi's induce cancer cell death by regulating important genes and proteins involved in the cancer process.
For ease of reference, we have listed internet resources where available; all sources were last accessed on 6 January 2004. Abbott, George W. and Sporn, Lee S., 2001. Trademark counterfeiting. Gaithersburg, Md: Aspen. Adobe, 2003. Preventing the piracy of Adobe software. Available at : adobe aboutadobe antipiracy main . Bartlett, Patrick, 2003. EU crackdown on counterfeit goods. BBC News, 20 January. Available at : news.bbc 2 hi europe 2678159 m. BBC News, 2002. Warning over fake cigarettes. BBC News, 11 July. Available at : news.bbc 1 hi england 2123054 m. China People's Daily, 2002. China battles illegal cigarette production, sales. China People's Daily, 12 July. European Anti-Fraud Office, 2003. Cigarette smuggling: Seven arrested in the Netherlands and three in Germany thanks to international cooperation. Press release, 6 May. Available at : europa .int comm anti fraud press room pr 2003 14 en . European Commission, 1998. Combating counterfeiting and piracy in the Single Market. Green paper. Available at : europa .int comm internal market en indprop piracy 922 . European Commission, 2003a. Customs: Counterfeiters and pirates are increasingly turning to massproduced goods. Press release IP 03 1589, 24 November. Available at : europa .int rapid start cgi guesten.ksh?p action.gettxt gt&doc IP 03 1589|0|RAPID&lg EN&display . European Commission, 2003b. Customs: Commission reports on implementation of the New Computerised Transit System NCTS ; . Press release IP 03 500, 7 April. Available at : europa .int rapid start cgi guesten.ksh?p action.gettxt gt&doc IP 03 500|0|RAPID&lg E N. European Commission Taxation and Customs Union, 2001. An evolving problem. Available at : europa .int comm taxation customs customs counterfeit piracy index en . European Commission Taxation and Customs Union, 2002a. Customs 2002 guide on the use of x-ray container scanners. Available at : europa .int comm taxation customs customs information notes c2002 xray . European Commission Taxation and Customs Union, 2002b. Relations with the trade. Available at : europa .int comm taxation customs customs information notes c2002 relations . European Commission Taxation and Customs Union, 2003. Statistics recorded at the external borders of the EU. Available at : europa .int comm taxation customs customs counterfeit piracy counterfeit8 en European Parliament, 1997. Report on the Community Transit System. Strasbourg, 20 February. Available at : europarl .int hearings kelletta default en . European Report, 2001. Less duty collecting, more crime busting the way ahead says Commission. European Report, 7 February. Fuller, Thomas, 2003. EU to tighten borders in war against fakes. International Herald Tribune, 21 January, p. 11. Goodman, Peter S., 2002. China's killer headache: Fake pharmaceuticals. Washington Post Foreign Service, 30 August, p. A01. Available at : zurichmednet features FakePharmaceuticals . Guerrera, Francesco, 2003. EU computers to fight duty fraud. Financial Times, 2 June, p. 7. Hopkins, David M., Kontnik, Lewis T. and Turnage, Mark T., 2003. Counterfeiting exposed: Protecting your brand and customers. Chichester: Wiley. International Anti-Counterfeiting Coalition, 2003. Submission to the United States Trade Representative: Special 301 recommendations. Washington, 13 February. Available at : iacc teampublish uploads Final301'03.
Taking echinacea while nursing
Goulard's solution answer all purposes and certainly are much more prompt and satisfactory than the many solutions of various tinctures recommended. In using these preparations care should be taken not to make mistakes as to stage and condition of the trouble. In the acute stage or purulent form a 2% solution of nitrate of silver should be used. That is 2% solution is considered average and may be made weaker or a little stronger as the case demands. Many prefer protargol to nitrate of silver in this stage. In the subacute or chronic form nitrate of silver or protargol have no value. In the subacute or chronic form zinc sulphate in 1 or 2% solution is a good remedy. In the chronic form Goulard's solution of lead is certainly the best. Generally 1 part is added to 10 parts of water. In severe cases it must be used stronger. In very old and severe cases it may even be used in full strength at first, then reduce strength gradually to the average of 1 part to 9 parts of water. In the healthy eye Goulard's solution will produce inflammation. To avoid Purulent conjunctivitis in new born children where vaginal infection is suspected a 2% solution of nitrate of silver instilled into the eyes is a good and safe remedy. Iritis of serious nature use mydriatics locally and tonics internally to build up system. Iritis of plastic nature use prompt means to stop plastic exudation. Think of ice applications locally. Internally, mercury, or echinacea in very large doses. Grindelia robusta is a good remedy in milder and non-purulent iritis and general inflammation of the eyes. Grindelia robusta 3 drachms; aqua pura 4 ounces. Soak a thin cloth in solution., then apply to the eyes and keep wet. Purulent ophthalmia, argentum nit. 30d is our best remedy. In keratitis atropine is a good remedy. In scrofulous keratitis, iodine may be used. Glaucoma: Electricity will improve nutrition. In acute or primary stage eserine is curative. In the secondary stage it is only helpful. Ulcerated: 1 part eucalyptus tincture to 8 parts of distilled water. Drop in the eye several times a day, will generally cure in a few days.
Weinstein, M. C. and W. B. Stason. "Foundations of Cost Effectiveness Analysis for Health and Medical Practices." New England Journal of Medicine, vol. 296 1977 ; , pp. 716-721. Weitzel, Jeffrey N. "Genetic Cancer Risk Assessment: Putting it all Together." Cancer, vol. 86, no. 11 Suppl December 1, 1999 ; , pp. 2483-2492. Williams, Gary M., Christine L. Williams, and John H. Weisburger. "Diet and Cancer Prevention: the Fiber First Diet." Toxicological Science, vol. 52, no. 2 Suppl 1999 ; , pp. 72-86. Wolfe, Elizabeth S. and William W. Wolfe, Sr. "Discussion of the Controversies Associated with Prostate Cancer Screening." Journal of the Royal Society of Health, vol. 117, no. 3 June 1997 ; , pp. 151-155 and efalizumab.
A61K 36 074 36 Ganoderma [8] Poria [8] Lichens [8] Bryophyta mosses ; [8] Pteridophyta or Filicophyta ferns ; [8] . Filicopsida or Pteridopsida [8] Drynaria [8] Coniferophyta gymnosperms ; [8] . Cupressaceae Cypress family ; , e.g. juniper or cypress [8] . Pinaceae Pine family ; , e.g. pine or cedar [8] Ginkgophyta, e.g. Ginkgoaceae Ginkgo family ; [8] Gnetophyta, e.g. Ephedraceae Mormon-tea family ; [8] Magnoliophyta angiosperms ; [8] . Magnoliopsida dicotyledons ; [8] Acanthaceae Acanthus family ; [8] . Strobilanthes [8] Aceraceae Maple family ; [8] Amaranthaceae Amaranth family ; , e.g. pigweed, rockwort or globe amaranth [8] Anacardiaceae Sumac family ; , e.g. smoketree, sumac or poison oak [8] Apiaceae or Umbelliferae Carrot family ; , e.g. dill, chervil, coriander or cumin [8] . Angelica [8] . Bupleurum [8] . Cnidium snowparsley ; [8] . Foeniculum fennel ; [8] . Ligusticum licorice-root ; [8] . Notopterygium [8] . Saposhnikovia [8] Apocynaceae Dogbane family ; , e.g. plumeria or periwinkle [8] Araliaceae Ginseng family ; , e.g. ivy, aralia, schefflera or tetrapanax [8] . Acanthopanax or Eleutherococcus [8] . Panax ginseng ; [8] Aristolochiaceae Birthwort family ; , e.g. heartleaf [8] . Aristolochia Dutchman's pipe ; [8] . Asarum wild ginger ; [8] Asclepiadaceae Milkweed family ; , e.g. hoya [8] Asteraceae or Compositae Aster or Sunflower family ; , e.g. chamomile, feverfew, yarrow or echinacea [8] . Artemisia, e.g. wormwood or sagebrush [8] . Atractylodes [8] . Aucklandia [8] . Carthamus distaff thistle ; [8] . Chrysanthemum, e.g. daisy [8] . Taraxacum dandelion ; [8] . Vladimiria [8] Berberidaceae Barberry family ; , e.g. barberry, cohosh or mayapple [8] . Epimedium [8] Boraginaceae Borage family ; , e.g. comfrey, lungwort or forget-me-not [8] Brassicaceae or Cruciferae Mustard family ; , e.g. broccoli, cabbage or kohlrabi [8] . Isatis, e.g. Dyer's woad [8] Burseraceae Frankincense family ; [8] . Boswellia, e.g. frankincense [8] 36 328 36 Commiphora, e.g. mecca myrrh or balm of Gilead [8] . Cactaceae Cactus family ; , e.g. pricklypear or Cereus [8] . Campanulaceae Bellflower family ; [8] . Adenophora [8] . Codonopsis [8] . Platycodon [8] . Caprifoliaceae Honeysuckle family ; [8] . Lonicera honeysuckle ; [8] . Caryophyllaceae Pink family ; , e.g. babysbreath or soapwort [8] . Celastraceae Staff-tree or Bittersweet family ; , e.g. tripterygium or spindletree [8] . Clusiaceae, Hypericaceae or Guttiferae Hypericum or Mangosteen family ; , e.g. common St. Johnswort [8] . Convolvulaceae Morning-glory family ; , e.g. bindweed [8] . Cornaceae Dogwood family ; [8] . Crassulaceae Stonecrop family ; [8] . Cucurbitaceae Cucumber family ; [8] . Gynostemma [8] . Trichosanthes [8] . Cuscutaceae Dodder family ; , e.g. Cuscuta epithymum or greater dodder [8] . Ebenaceae Ebony family ; , e.g. persimmon [8] . Ericaceae or Vacciniaceae Heath or Blueberry family ; , e.g. blueberry, cranberry or bilberry [8] . Eucommiaceae Eucommia family ; , e.g. hardy rubber tree [8] . Euphorbiaceae Spurge family ; , e.g. Ricinus castorbean ; [8] . Fabaceae or Leguminosae Pea or Legume family Caesalpiniaceae; Mimosaceae; Papilionaceae [8] . Astragalus milkvetch ; [8] . Cassia, e.g. golden shower tree [8] . Gleditsia locust ; [8] . Glycyrrhiza licorice ; [8] . Gueldenstaedtia [8] . Millettia [8] . Psoralea [8] . Pueraria kudzu ; [8] . Sophora, e.g. necklacepod or mamani [8] . Fagaceae Beech family ; , e.g. oak or chestnut [8] . Fumariaceae Fumitory family ; , e.g. bleeding heart [8] . Corydalis [8] . Gentianaceae Gentian family ; [8] . Gentiana [8] . Juglandaceae Walnut family ; [8] . Lamiaceae or Labiatae Mint family ; , e.g. thyme, rosemary or lavender [8] . Agastache, e.g. giant hyssop [8] . Leonurus motherwort ; [8] . Mentha mint ; [8] . Perilla beefsteak plant ; [8] . Prunella or Brunella selfheal ; [8] . Salvia sage ; [8] . Schizonepeta [8] . Scutellaria skullcap ; [8] . Lauraceae Laurel family ; , e.g. cinnamon or sassafras [8] Int.Cl. 2007.10 ; , Section A.
Echinacea medicinal uses
Ingredients - per 2 capsules: thymus 260 mg; lymph 160 mg; spleen 160 mg; echinacea herb 202 mg; goldenseal root 66 mg; clove 35 mg other ingredients: 100% natural homeopathic nutrients: calc phos 3x, calc sulph 3x, kali mur 3x, nat mur 6x, silica 6x sku: 076280052008 category: solaray vitamins t nature's way's daily two multi iron-free ; 180tabs nature's way'sdaily two multi iron-free ; 180tabs sku: 033674451151 category: nature's way vitamins d solgar's lecithin 300mg 4gr ; 100sg suggesteduse: as a dietary supplement for adults, six 6 ; softgels daily, preferably at mealtime, or as directed by a healthcare practitioner and eletriptan.
Yellow fever remains contraindicated for pregnant women, but under certain circumstances vaccination during the second trimester can be envisaged. It was reported from Latin-America that the immunoresponse was adequate and that there were no problems for the pregnancy nor the baby. It therefore seems not necessary to revaccinate after delivery, to obtain a 10 year protective antibody level.
Bronchitis is the inflammation of the bronchi, which are the breathing tubes that lead to the lungs. This inflammation leads to a build up of mucus, which obstructs breathing and causes a chronic cough. It can be triggered by smoking or pollutants or caused by a virus or bacterial infection. Herbs that can assist with bronchitis are Astragalus A natural antibiotic that helps clear mucus. Do not use in the presence of a fever! Black Radish Improves lung congestion and circulation Boneset Contains compounds that help reduce mucus in the lungs. Caution Do not use for more than one week as it is cumulative in the system and can be toxic! Chickweed Moistens the lungs and clears up lung congestion Coltsfoot Soothes the throat and tames a cough Echinacea A powerful antibacterial and anti-viral agent Ephedra Relaxes spasms of the bronchial tubes. Warning! Don't take ephedra if you suffer from anxiety, glaucoma, heart disease, high blood pressure or are taking medications for insomnia or depression. Gingko Biloba Improves microcirculation in the lungs Golden Seal Purifies the blood and acts as an antibacterial and anti-viral agent Lobelia - The extract is an expectorant and relaxant of the smooth bronchial muscles Mullein Improves circulation and relieves chest cough Myrrh A natural antibiotic and anti-viral agent Pau d'arco A natural antibiotic Slippery Elm Bark Calms a cough and soothes the throat. Wild Cherry Bark - Soothes the throat and is good for a cough and elidel.
Echinacea can help speed up wound healing and also prevents dry skin.
That reside and function therein, i.e. the cells mediating specific adaptive ; immunity T and B lymhocytes ; , as well as NK cells and monocytes--both types being responsible for nonspecific, spontaneous and non-adaptive immunity. Other cells involved in the disease defense process, i.e. the mature and maturing cells of the granulocyte lineages eosinophils, neutrophils and basophils ; also either function in the spleen or pass through it en route elsewhere. In our analysis of the effect of Echinacea on the abovementioned cells, everything was standardized. The mice were inbred and of identical age, weight and gender male ; . Moreover, housing conditions were identical between cages of mice consuming Echinacea and those consuming untreated diet. The quantity and quality of food and water were also standardized among all cages--those receiving the herb in the diet and those not given the herb controls ; . It is obviously of fundamental importance that Echinacea itself, as with any agent given either prophylactically or therapeutically, is not deleterious to the host. In the case of Echinacea, there appears to be no vivo toxic level, i.e. overdose level, as defined by several assays and criteria 6, 18, 19 ; . The immunostimulating effects of Echinacea in vivo are exclusive to cells mediating spontaneous immunity and their accessory cells, i.e. NK cells and monocytes 17 ; . While Echinacea appears to be tailor-made for its highly positive influences on this arm of the immune system, there are instances, in vivo, where use of this herb may be contraindicated. For example, individuals demonstrating allergy to members of the Family Asteraceae, to which Echinacea belongs, would clearly be ill-advised to consume this herb for any reason 20, 21 ; . Moreover, there is very little available information concerning the potential for detrimental interactions of Echinacea with either other herbs or pharmaceuticals 22 ; . Another problem pertains to the choice of the most effective source of Echinacea as NK stimulant--not an insignificant problem since there is extremely wide variation in the quality of Echinaceas from assorted commercial sources. For our experiments, we chose a product from a commercial supplier, which we proved was consistent in quality and NK stimulating potency, and revealed in doseresponse analyses, a progressive increment in NK cell numbers up to a maximum plateau ; beyond which no further increase in NK cells occurred. It was this dosage that we have used throughout our experiments to date, including those reported in this review. Should Echinacea be Taken When Healthy? When healthy young adult mice consumed Echinacea daily in their diet for 7 days, we found significantly more NK cells, identified by our standard immunoperoxidase labeling methods, in their bone marrow than in the bone marrow of mice consuming untreated diet P 0.01 ; , while the spleens of mice consuming Echinacea had 25% more NK cells, which is a clear elevation in number although not yet statistically significant 17 ; . By weeks, however, those mice consuming the and eligard.
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Fig. 2 Effect of stratification at 3-5C Experiment 1 ; or 0-1 C Experiment 2 ; for periods ranging from 0 to 18 weeks on the time taken in days after removal from the chiller ; for Echinacea to reach maximum germination percentage. A, Comparison of E. purpurea and E. angustifolia in Experiment 1; B, comparison of trimmed and untrimmed seed of E. angustifolia in Experiment 1; and C, comparison of trimmed and untrimmed seed of E. angustifolia in Experiment 2. Vertical bars are SEDs.
Evidence shows: as people gain literacy skills, they are more likely to understand their health problems, have both the confidence and knowledge they need in order to find appropriate medical care, and follow their treatment regimens properly and elmiron.
Of total endogenousCAMP in cultured olfactory receptor neurons and employing an assumptionthat tissueis approximately 10%protein. Theselevels are similar to those in liver and brain Gilman, 1970 ; . Nakamura and Gold 1987 ; detected two types of cyclic nucleotide-gated channels in olfactory receptor neurons, with K * values of 1O-6and lo + M. Given such a highly active conductance, odorant stimulation mediatedvia elevation of cyclic nucleotides would require basal levels of CAMP and cGMP to be approximately lo-' M or less.Such a systemmight also require the presenceof a high-affinity PDE. Brain CAMPDE is one of the most active in the body Butcher and Sutherland, 1962 ; . At the low micromolar physiological concentrations of CAMP, enzyme activity in olfactory epithelium is four to five times greater than in brain. In most mammalian tissues, the predominant CAM-PDE is the low-affinity enzyme Beavo, 1988 ; so that olfactory epithelium is notable in having a CAMPDE with apparent high affinity for CAMP. The Hill coefficient for PDE activity is almost 0.9 in brain, but 0.4-0.5 in cilia, olfactory mucosa, and respiratory epithe.
Displaced with the same pharmacology as that of intact DATs. These results verify numerous aspects of DAT structure and topology heretofore only predicted from theoretical considerations and extend our knowledge of DAT structure-function properties and eloxatin.
While you can't always eliminate stressful circumstances, you can diffuse their impact by changing the way you view and respond to them. According to stress experts, 90% of the stress we face comes not from an event itself, but from our perception of it and echinacea.
Hand, it has been postulated that anandamide binds first to the lipid-bilayer and then moves into the receptor 47 ; , implying a time-resolved diffusion. Since release of [Ca2 + ]i occurs rapidly 100 ms ; and is measured real-time it is possible that anandamide modulates [Ca2 + ]i outside the time-window normally chosen for such measurements. Preliminary data show that alkylamides from Echinacea also elevate total [Ca2 + ]i in Jurkat T-cells data not shown ; . The fact that Jurkat T-cells produce CB2 mRNA 48 ; , but exhibit only very low surface CB2 protein expression unpublished data ; , may also suggest that a second receptor is involved in Ca2 + -signaling for alkylamides, but also 2-AG. This is also indicated by the fact that SR144528 is not able to fully inhibit [Ca2 + ]i in HL60 cells induced by 2-AG and alkylamides Fig. 5C ; . It has recently been shown that -9 tetrahydrocannabinol THC ; induces a Ca2 + influx in resting T-cells in a cannabinoid receptor-dependent manner 49 ; . Together with the data presented in this study the latter finding indicates that the known inhibitory effect on cAMP production mediated by CB2stimulation 50 ; is unlikely to represent the only mechanism underlying immune modulation by cannabinoids. As cannabinoids including the endogenous cannabinoids ; have been reported to exert anti-inflammatory and immunosuppressive effects both in vitro and in vivo 18; 19 ; , we also studied the actions of alkylamides A1-A3, anandamide, and SR144528 on untreated and stimulated human whole blood. Overall, CD3- and CD28stimulated whole blood showed both TH1- and TH2-type cytokine expressions Table 2 ; , whereas LPS resulted in the characteristic expression of IL-1, IL-6, IL-8, and TNF- not shown ; . Interferon-gamma expression was not measured. In our system 18 h incubation of undiluted heparinized whole blood ; , only IL-1, IL-6, IL-7, and IL-8 were constitutively expressed 20 pg mL ; under non-stimulating conditions. The CB2-binding compounds A1, A2, and anandamide significantly up-regulated constitutive IL-6 expression Fig. 7 ; . As the up-regulation of IL-6 in human whole blood cultures was strongly inhibited by SR144528, and the non-CB2-binding compound A3 did not show an effect on constitutive IL-6, it is likely that the up-regulation of IL-6 expression is and emend.
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1. Mitchell MF, Hittelman WN, Hong WK, Lotan R, Schottenfeld D. "The natural history of cervical intraepithelial neoplasia: an argument for intermediate endpoint biomarkers" Cancer Epidemiol. Biomarkers Prev. 1994; 3: 619-26 Koss LG. "The Papanicolaou test for cervical cancer detection. A triumph and a tragedy" JAMA 1989; 261: 737-43 Kurman RJ, Henson DE, Herbst AL, Noller KL, Schiffman MH. "Interim guidelines for management of abnormal cervical cytology. The 1992 National Cancer Institute Workshop" JAMA 1994; 271: 1866-9 Hornung R, Pham TH, Keefe KA, Berns MW, Tadir Y, Tromberg BJ. "Quantitative nearinfrared spectroscopy of cervical dysplasia in vivo". Human Reproduction 1999; 14: 29082916. DiSaia, Creasman. "Clinical Gynecologic Oncology" Mosby Year Book 1993, St. Louis, Missouri. 4th edition. Chapter 1. 6. Coppleson "Gynecologic Oncology. Fundamental Principles and Clinical Practice" Churchill Livingston, Longman Group Limited New York 1981, volume 1; chapter 32-33. 7. Hopman E, Kenemans P, Helmerhorst Th. "Positive Predictive Rate of Colposcopic Examination of the Cervix Uteri: An Overview of Literature" Obstet Gynecol Survey 1998; 53: 97-106 Sellors J, Nieminen P, Vesterinen E, Paavonen J. "Observer Variability in the Scoring of Colpophotographs" Obstet Gynecol 1990; 76: 1006-1008 Ismail SM, Colclough AB, Dinnen JS, Eakins D, Evans DM, Gradwell E, O'Sullivan JP, Summerell JM, Newcombe RG. "Observer variation in histopathological diagnosis and grading of cervical intraepithelial neoplasia" Br Med J 1989; 298: 707-710 Buxton E, Luesley D, Shafi M, Rollason M. "Colposcopically directed punch biopsy: a potentially misleading investigation Br J Obstet Gynecol 1991; 98: 1273-"1276.
Echinacea echinacea purpurea north american indians used it for centuries and emtricitabine.
Satisfaction can be anticipated, with the exception of the group of patients with fibrotic corpora cavernosa. The cause of dissatisfaction in this group does not appear to be associated only with the diminished penile length that occurs with this condition. POD-05.09 A 6 month interim analysis of the effect of nightly intraurethral alprostadil vs sildenafil on penile morphometrics after nerve sparing radical prostatectomy NSRRP ; Fenig D, Robbins D, Brassil D, Goodwin B, McCullough A New York University School of Medicine, New York, NY, USA Introduction: Observational cross sectional and prospective longitudinal studies have reported the rapid loss of penile length and circumference after radical prostatectomy. The cause is hypothesized to be due to the chronic hypoxia that occurs with the loss of erectile during the obligate temporary period of neuro praxia after nerve sparing prostatectomy. Methods: As part of a randomized prospective comparative study of the effect of nightly intraurethral alprostadil M ; vs sildenafil S ; flaccid penile circumference and length and stretched penile length was measured preoperatively, and postoperatively at 1week, and 1.25, 3, 6, and 11 months after surgery. Penile measurements were made with both a tape measure and ruler. Results: Forty-two men were followed serially for 6 months 31 M, 11 S ; There was no significant difference between the measurements of M vs groups at any time interval. Whereas there was no significant change in circumference during the follow up period, flaccid and stretched length decreased as soon as one week and did not increase during the follow up period. The 6.6% decrease appears less than contemporary series 10-15%. The and efalizumab.
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