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How can someone with HCV infection prevent spreading HCV to others? Use the following precautions: Do not share personal items that might have your blood on them such as toothbrushes, dental appliances, razors, or nail-grooming equipment Cover your cuts and skin sores. Don't have unprotected sex Don't share needles, tattoo or body piercing equipment. FIGURE 5-12 Thiazolidinediones lower blood pressure in several models of experimental hypertension and in obese humans. FIGURE 5-13 Agents that increase insulin sensitivity, decrease plasma lipid concentrations, and lower blood pressure in animal models and preliminary studies in humans. FIGURE 3. Plots of band shift data for trp RNA A ; , trp RNA with the GGG 3 CCC change in the terminator stem B ; , and trp leader RNA with a poly A ; tail C ; . Data are the average of 4 experiments S.D. The lines drawn are the theoretical curves calculated as described under "Experimental Procedures." Dashed lines, without TRAP; solid lines, with TRAP. To the right of each plot are schematic diagrams showing the predicted structure of the trp leader RNA with and without TRAP bound, as well as the respective Kapp values. At the beginning of the eighteenth century, commerce had not indeed assumed those features, or reached that form and dimensions by which it was distinguished at the end of this century; but as its dimensions gradually enlarge, it will be necessary to be less particular and more condensed. Our plan indeed of being more minute in the early history of geographical science and commercial enterprise, is founded on an obvious as well as a just and important principle. In the infancy of geography and commerce, every fact is important, as reflecting light on the knowledge and state of mankind at that period, and as bearing on and conducing to their future progress; whereas when geography and commerce have been carried so far as to proceed in their course as it were by their own internal impulse, derived from the motion they have been acquiring for ages, their interest and importance is much diminished from this cause, as well as from the minuteness of the objects to which, --all the great ones having been previously occupied by them, --they must necessarily be confined. Several circumstances co-operated to direct geographical discovery, during the eighteenth century, principally towards the north and north-east of Asia, and the north-west of America. The tendency and interest of the Russian empire to stretch itself to the east, and the hope still cherished by the more commercial and maritime nations of Europe, that a passage to the East Indies might be discovered, either by the north-east round Asia, or by the north-west, in the direction of Hudson's Bay, were among the most powerful of the causes which directed discovery towards those parts of the globe to which we have just alluded. The extent of the Russian discoveries and conquests in the north and north-east of Asia, added much to geographical knowledge, though from the nature of the countries discovered and conquered, the importance of this knowledge is comparatively trifling. About the middle of the seventeenth century, they ascertained that the Frozen Ocean washed and bounded the north of Asia: the first Russian ship sailed down the river Lena to this sea in the year 1636. Three years afterwards, by pushing their conquests from one river to another, and from one rude and wandering tribe to another, they reached the eastern shores of Asia, not far distant from the present site of Ochotsk. Their conquests in this direction had occupied them nearly sixty years; and in this time they had annexed to their empire more than a fourth part of the globe, extending nearly eighty degrees in length, and in the north reaching to the 160 of east longitude; in breadth their conquests extended from the fiftieth to the seventy-fifth degree of north latitude. This conquest was completed by a Cossack; another Cossack, as Malte Brun observes, effected what the most skilful and enterprising of subsequent navigators have in vain attempted. Guided by the winds, and following the course of the tides, the current and the ice, he doubled the extremity of Asia from Kowyma to the river Anadyn. Kamschatcka, however, which is their principal settlement in the east of Asia, was not discovered till the year 1690; five years afterwards they reached it by sea from Ochotsk, but for a long time it was thought to be an island. The Kurile Islands were not discovered till the beginning of the eighteenth century. The direction of discovery to this part of the world, as well as the plan by which it might be most advantageously and successfully executed, was given by Peter the Great, and affords one proof, that his mind was capacious, though his manners, morals, and conduct, might be those of a half-civilized tyrant. Peter did not live to carry his plan into execution: it was not, however, abandoned or neglected; for certainly the Russian government, much more than any other European government, seems to pursue with a most steady and almost hereditary predilection, all the objects which have once occupied its attention and warmed its ambition. On his death, his empress and her successors, particularly Anne and Elizabeth, contributed every thing in their power to carry his plan into full and complete execution. They went from.

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