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The widely used Pari-Master nebulizer system can efficiently and homogeneously deliver IFNg to the lungs in healthy volunteers. Even at the highest doses, this cytokine shows no systemic effects. This type of study could be applied for the effective clinical dosing of IFNg for patients with lung disease undergoing IFNg inhalation treatment.
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N. Korsun1, Z. Mladenova1, L. Andonova2, M. Tiholova2. 1National Center of Infectious and Parasitic Diseases, National Enterovirus Laboratory, Sofia, Bulgaria; 2Medical University, Sofia, Bulgaria Background: Enteroviruses are the most common cause of aseptic meningitis and encephalitis. The rapid etiologic diagnosis of neuroinfections is essential in the management of patients. Detection of enterovirus RNA in cerebrospinal fluid CSF ; has proven to be more rapid and sensitive than viral cultures. The aim of this study was to compare the performance of the viral cultures with RT-PCR. Methods: 88 patients with aseptic meningitis and 28 patients with meningoencephalitis, ages 6 months75 years hospitalized in different regions in Bulgaria during 2006 were included in this study. A total of 106.
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AECTCV Archives of Environmental Contamination and Toxicology, 12, 355-382, 1985 ; !SIDSP * OECD SIDS. Screening Information Data Set SIDS ; of OECD High Production Volume Chemicals Programme, 1993 and tipranavir.
Moder och hans brder kommo och skte honom, men fr folkets skull kunde de icke komma in till honom. 20D sade man till honom: Din moder och dina broder st hrutanfr och vilja trffa dig. 21Men han svarade och sade till dem: Min moder och mina brder ro dessa, som hra Guds ord och gra det. 22En dag steg han med sina lrjungar i en bt och sade till dem: Lt oss fara ver sjn till andra sidan. Och de lade ut. 23Och medan de seglade fram, somnade han. Men en stormvind for ned ver sjn, och deras bt begynte fyllas med vatten, s att de voro i fara. 24D gingo de fram och vckte upp honom och sade: Mstare, Mstare, vi frgs. Nr han s hade vaknat, npste han vinden och vattnets vgor, och de stillades, och det blev lugnt. 25Drefter sade han till dem: Var r eder tro? Men de hade blivit hpna och frundrade sig och sade till varandra: Vem r d denne? Han befaller ju bde vindarna och vattnet, och de lyda honom. 26S foro de ver till gerasenernas land, som ligger mitt emot Galileen. 27Och nr han hade stigit i land, kom en man frn staden emot honom, en som var besatt av onda andar, och som under ganska lng tid icke hade haft klder p sig och icke bodde i hus, utan bland gravarna. 28D nu denne fick se Jesus, skriade han och fll ned fr honom och sade med hg rst: Vad har du med mig att gra, Jesus, du Guds, den Hgstes, son? Jag beder dig, plga mig icke. 29Jesus skulle nmligen just bjuda den orene anden att fara ut ur mannen. Ty i lng tid hade han farit svrt fram med mannen; och vl hade denne varit fngslad med kedjor och fotbojor och hllits i frvar, men han hade slitit snder bojorna och hade av den onde anden blivit driven ut i knarna. 30Jesus frgade honom: Vad r ditt namn? Han svarade: Legion. Ty det var mnga onda andar som hade farit in i honom. 31Och dessa bdo Jesus att han icke skulle befalla dem att fara ned i avgrunden. 32Nu gick dr en ganska stor svinhjord i bet p berget. Och de bdo honom att han ville tillstdja dem att fara in i svinen. Och han tillstadde dem det. 33D gvo sig de onda andarna stad ut ur mannen och foro in i svinen. Och hjorden strtade sig utfr branten ned i sjn och drunknade. 34Men nr herdarna sgo vad som hade skett, flydde de och berttade hrom i staden och p landsbygden. 35Och folket gick ut fr att se vad som hade skett. Nr de d kommo till Jesus, funno de mannen, ur vilken de onda andarna hade blivit utdrivna, sitta invid Jesu ftter, kldd och vid sina sinnen; och de betogos av hpnad. 36Och de som hade sett hndelsen omtalade fr dem huru den besatte hade blivit botad. 37Allt folket ifrn den kringliggande trakten av gerasenernas land bad d Jesus att han skulle g bort ifrn dem, ty de voro gripna av stor frskrckelse. S steg han d i en att vnda tillbaka. 38Och mannen, ur vilken de onda andarna hade blivit utdrivna, bad honom att f flja honom. Men Jesus tillsade honom att g, med de orden: 39Vnd tillbaka hem, och frtlj huru stora ting Gud har gjort med dig. D gick han bort och frkunnade i hela staden huru stora ting Jesus hade gjort med honom. 40Nr Jesus kom tillbaka, mottogs han av folket; ty alla vntade de p honom. 41D kom dr en man, vid namn Jairus, som var frestndare fr synagogan. Denne fll ned fr Jesu ftter och bad honom att han skulle komma till hans hus; 42ty han hade ett enda barn, en dotter, vid pass tolv r gammal, som lg fr dden. Men under det att han var p vg dit.
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7. Og byens mur blev gjennembrutt, og alle krigsmennene flyktet og drog ut av byen om natten gjennem porten mellem begge murene ved kongens have, mens kaldeerne l leiret mot byen rundt omkring; og de tok veien til demarken. 8. Men kaldeernes hr satte efter kongen, og den ndde Sedekias igjen p Jerikos demarker; og hele hans hr spredte sig og forlot ham. 9. Og de grep kongen og frte ham op til Babels konge i Ribla i Hamatlandet, og han avsa dom over ham. 10. Og Babels konge drepte Sedekias' snner for hans ine; ogs alle Judas hvdinger drepte han i Ribla. 11. Og Babels konge lot Sedekias blinde, og han lot ham binde med to kobberlenker og frte ham til Babel og holdt ham i fengsel til hans ddsdag. 12. I den femte mned, p den tiende dag i mneden - det var Babels konge Nebukadnesars nittende r - kom Nebusaradan, hvdingen over livvakten, en av de hieste menn hos kongen i Babel, til Jerusalem. 13. Han brente op Herrens hus og kongens hus, og alle Jerusalems hus - alle stormennenes hus - brente han op med ild. 14. Og hele den hr av kaldeere som hvdingen over livvakten hadde med sig, rev ned alle murene omkring Jerusalem. 15. Nebusaradan, hvdingen over livvakten, bortfrte nogen av de ringeste av folket og resten av folket, dem som var blitt tilbake i byen, og overlperne som var gtt over til kongen i Babel, og resten av hopen. 16. Bare nogen av de ringeste i landet lot Nebusaradan, hvdingen over livvakten, bli tilbake som vingrdsmenn og jordbrukere. 17. Kaldeerne slo i stykker kobbersilene i Herrens hus og fotstykkene og kobberhavet i Herrens hus og frte alt kobberet av dem til Babel. 18. De tok ogs askebttene og ildskuffene og knivene og bollene til sprenge blod med og rkelsesklene og alle kobberkarene som hadde vrt brukt til tjenesten. 19. Ogs sklene og fyrfatene og bollene til sprenge blod med og askebttene og lysestakene og rkelsesklene og begerne, alt som var av gull, og alt som var av slv, det tok hvdingen over livvakten. 20. De to siler, det ene hav og de tolv kobberokser som var under fotstykkene som kong Salomo hadde latt gjre for Herrens hus - i alle disse ting var kobberet ikke til veie. 1286 and tobi.
1 2 The Sphere Project. Humanitarian charter and minimum standards in disaster response. Oxford: Oxfam Publishing, 2004. World Health Organization. WHO appeals for US$ 66 million to prevent disease outbreaks in tsunami-affected Southeast Asia; 150 000 people at `extreme risk' of dying of preventable disease. who.int mediacentre news releases 2005 pr01 en index accessed 20 May 2005 ; . Chan CC, Lin YP, Chen HH, Chang TY, Cheng TJ, Chen LS. A population-based study on the immediate and prolonged effects of the 1999 Taiwan earthquake on mortality. Ann Epidemiol 2003; 13: 502-8. Kysely J. Mortality and displaced mortality during heat waves in the Czech Republic. Int J Biometeorol 2004; 49: 91-7. Depoortere E, Checchi F, Broillet F, Gerstl S, Minetti A, Gayraud O, et al. Violence and mortality in West Darfur, Sudan 2003-04 ; : epidemiological evidence from four surveys. Lancet 2004; 364: 1315-20.
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Female carrying 2 young infants, and speculated that this was an adoption since another bonnet female had been killed several days before. In none of these reports were any deAdaptation and the Problem of Survival tails given concerning the behavior by Our observation of major behavioral the infant which might have led to the changes in the infant in response to the adoption; nor was the behavior deloss of the mother is concordant with the scribed of the other animals in the setother evidence. Various observations and ting just prior to the adoption. Yet both reviews"" 1 4 have documented the seem important as determinants of occurrence of severe reactions in animals whether an adoption will take place. to the loss of close objects, especially in In our own experimental studies with infants to the loss of mother. Obviously bonnets we have seen numerous adopthe loss of mother poses a serious prob- tions, but this will form the basis for a lem for the survival of the infant. How- separate report. ever, for nonhuman primates there are Individual Variation and the Role of only meager data on what ultimately Hierarchical Factors happens to these separated infants under natural conditions. For the purpose of There is conflicting evidence concernthis discussion we exclude from consid- ing a youngster's behavior in the matter eration the important studies, especially of finding a substitute for a lost mother. those by Harlow, of infants reared in Freud and Dann, 1'2 in their study of conalmost total isolation and stimulus depri- centration camp children, found that the vation in the laboratory. children used whomsoever they could to First of all, there would appear to be relate to, in that case to each other. The great survival value in a mechanism study by Jensen and Tolman31 indicated which provided a substitute caretaker, that a pigtail infant separated from its as by adoption. Zuckerman08 reported mother will attempt to relate to a strange that a young female baboon became mother, and stops only when rebuked. very close to a "bachelor" after the death On the other hand, it is well known that of her mother. He later became her only children separated from their mothers companion. DeVore13 reported an ap- often refuse the ministrations of stranparent adoption by a beta male baboon gers. It seems likely that these differof a sick female infant. When observa- ences are due to a number of factors, tions began he noted 2 very emaciated including: 1 ; differences in developadult females, who then disappeared mental levels; 2 ; their being manifestawithin a few days. "One of these females tions of different stages of the reaction to was apparently our italics ; the sick in- separation; 3 ; differences in the confant's mother." The male protected the textual situation; and 4 ; individual infant who became his constant com- variation based on genetic and experipanion. Rowell et al.62 reported that an ential, including sociocultural, deter8-month-old rhesus infant whose mother minants. died was adopted by an infantless "aunt" There are at least two components inwho had been a close companion of the volved in successful turning to a substimother. They pointed out the obvious tute. The first is the effort by the infant survival value of such an adoption, and to do so, and the second is the nature stressed the previous close relationship of the adult responses. Both of these are between mother and "aunt." Jav30 re- likely to be modified by previous experiported that she had observed a bonnet ence. The adoption cited by Rowell et and tolcapone.
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Chromocytoma. Yale J. Biol. & Med. 24: 26 Sept. ; , 1951. The authors present two cases of pheochromocytoma in young adults. In one case, the hypertension was not paroxysmal, in the other, it was sustained but was sharply increased by histamine. The first patient died after an incomplete exploratory operation and the second patient was successfully operated on. The role of various pharmacologic agents in the symptomatology, diagnosis and management are discussed. It is stressed that most of the drug tests can give both false-negative and false-positive results. Since serious reactions can occur in patients with pheochromocytoma receiving histamine and in patients with essential hypertension receiving benzodioxane, the suggestion is made that the latter drug be used when the diagnosis of pheochromocytoma seems probable and that histamine be used as a screening procedure in cases of sustained hypertension when there is no evidence of pheochromocytoma. It is also felt that Arterenol is more useful than epinephrine in preventing postoperative peripheral vascular collapse after removal of the tumor in a case with marked preoperative response to Dibenamine. ENSELBERG and tolmetin.
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